long covid

Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation [Line breaks added] Background: Subjects with Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC)...

Autonomic dysfunction and vasoregulation in Long COVID-19 are linked to anti-GPCR autoantibodies [Line breaks added] Background SARS-CoV-2-triggered autoantibodies (AAB) targeting G protein-coupled receptors (GPCRs) have been suggested to contribute to the post-acute sequelae of COVID-19...

Effectiveness of inspiratory muscle training and multicomponent physical training in patients with post-COVID conditions: a systematic review and meta-analysis https://link.springer.com/article/10.1186/s13643-025-02982-1 BMC Systematic reviews Abstract Background There is evidence that fatigue...

Abstract: Long COVID, defined by symptoms persisting three months post-SARS-CoV-2 infection, presents a significant global health and economic challenge, with global prevalence estimated at 36% (ranging from 1–92%). This brief communication consolidates current knowledge on its economic...

A region-specific brain dysfunction underlies cognitive impairment in long COVID brain fog [Line breaks added] Abstract Long COVID "brain fog" is a common and debilitating subjective syndrome often associated with persistent cognitive impairment after COVID-19 infection. Here we identify a...

Association of Long COVID-Related inflammatory Processes in the Musculoskeletal System: 12-Month Longitudinal Cohort Feasibility Study Background A subset of individuals develops persistent symptoms following SARS-CoV-2 infection, including musculoskeletal (MSK) manifestations, a condition...

Differential Characteristics and Comparison Between Long-COVID Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Abstract Long-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome are disabling diseases characterised by ongoing fatigue, post-exertional malaise...

Evidence for a severe cognitive subgroup in a comprehensive neuropsychological Post-COVID-19 syndrome classification [Line breaks added] Abstract Approximately 7% of adults develop Post-COVID-19 syndrome (PCS). Cognitive impairment is common, but its profile in PCS is not well defined and...

Protocol See next post for the Trial Report Full title: Randomised, controlled, open-label pragmatic trial evaluating changes in functional exercise capacity after primary care PUlmonary REhabilitation in patients with long COVID: protocol of the PuRe-COVID trial in Belgium Introduction Long...

The Central Role of Macrophages in Long COVID Pathophysiology McMillan, Philip; Turner, Anthony; Uhal, Bruce [Line breaks added] Abstract This review article attempts to provide a unifying hypothesis to explain the myriad of symptoms and predispositions underlying the development of PASC...

Article from The Sick Times reporting on different advocacy strategies used by patient groups around the world. Long COVID advocacy is more than lobbying Congress: Here are some ways to get involved Subtitle: People with infection associated chronic conditions (IACCs) use a broad range of...

Abstract 4344995: Prognostic value of cardiac computed tomography delayed enhancement in individuals with post-acute sequelae of COVID-19 [Line breaks added] Introduction/Background Post-acute sequelae of COVID-19 (PASC) have been recognized as serious complications of SARS-CoV-2 infection...

Abstract 4369416: Impact of Long COVID on Physical Activity and Sleep: a Matched Cohort Study using Wearable and EHR data From The All of Us Research Program [Line breaks added] Backround Long COVID (LC) is associated with negative health effects, but its impact on health behaviors such as...

Nirmatrelvir/ritonavir use reduces risk for long COVID in patients with immunodeficiency [Line breaks added] Selected paragraphs Our findings highlight the potential broad benefit of nirmatrelvir/ritonavir in reducing the risk of long COVID among patients with both primary and secondary...

Individualised aerobic and resistance exercise training improves exercise tolerance in individuals with Long COVID: findings from the PERCEIVE randomised controlled trial E Howden, L Burnham, J Smith, K Whitmore, K Morrison, R Hoare, Y Sata, Q Huynh, T Marwick [Line breaks added] Background...

Long COVID is an umbrella term for the heterogeneous long-term consequences of SARS-CoV-2 infection. It encompasses a wide spectrum of phenotypes (sometimes overlapping), and its underlying mechanisms might vary across and within phenotypes. Trials that do not account for this heterogeneity risk...

Synopsis of 2024 VA Long COVID Clinical Guidance for U.S. Veterans: Part 1, Nervous System–Related Symptoms Wander, Pandora L.; Awan, Omar; Neal, Jacqueline; Seidel, Ilana; Bell, Kelsie A.; Cassell, Andre; Fattal, Deema; Ng, Bernard; Pyne, Morgan L.; Rog, Lauren; Helfand, Mark [Line breaks...

Research to evaluate safety and impact of long COVID intervention with Ensitrelvir for National Cohort (RESILIENCE Study): A protocol for a randomized, double-blind, placebo-controlled trial Konishi, Keiji; Yamamoto, Shungo; Sada, Ryuichi Minoda; Asano, Kento; Onozuka, Daisuke; Tanaka...

“Everything Looks Normal”: Patient Narratives of Contested Legitimacy in Long COVID Medical Encounters Rhidenour, Kayla B.; Thompson, Charee M.; Babu, Sara; Kelpinski, Lindsay F. [Line breaks added] Abstract This study examines how individuals with long COVID navigate illness experiences when...

A Comparative Study of the Coagulation Systems and Inflammatory Profiles of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Patients with Long COVID Hayley Emma Arron Supervisor: Prof. Etheresia Pretorius Stellenbosch University [Line breaks added] Abstract Myalgic...