long covid

MicroRNA sequencing of peripheral blood mononuclear cells reveals significant expression changes in women with Long COVID Abstract Long COVID is a clinical condition marked by persistent symptoms like fatigue and brain fog, estimated to have affected many of post-SARS-CoV-2/COVID-19...

Psychological interventions for individuals with long COVID: a systematic review and meta-analysis Introduction Long COVID involves a variety of persistent symptoms after initial SARS-CoV-2 infection, affects multiple functional areas and requires multidisciplinary treatment. Objective This...

Prevalence of severe fatigue after SARS-CoV-2 infection in Norway: a prospective 2-year follow-up study Objectives This study aims to estimate the prevalence of long-lasting severe fatigue and identify possible risk factors in a 2-year follow-up of patients with predominantly mild-to-moderate...

Metacognition and cognitive dysfunction in post-COVID condition Background The mechanisms associated with cognitive issues in post-COVID condition (PCC) are still under debate. Metacognition refers to the ability to reflect and evaluate one’s cognitive functioning and remains unexplored in...

Between silence and solutions: a global guideline review of long COVID care and services in Australia https://link.springer.com/article/10.1186/s12913-026-14268-w Background As the acute response to the COVID-19 pandemic shifts to long-term management, the lasting effects of infection are...

Persistent class switch toward spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination in post-acute infection syndrome: an exploratory cohort study Ana M. Espino, Carlimar Ocasio-Malavé, Riseilly Ramos, Ramon Sanmartin, Jesus Castro-Marrero Abstract Myalgic...

Disequilibrium, Rather than Postural Orthostatic Tachycardia Syndrome, Is the Primary Determinant of Orthostatic Intolerance in Patients with Long COVID Miwa, Kunihisa Background Orthostatic intolerance (OI) is an important factor affecting daily functional capacity in patients with long...

Autoimmune Disease is Associated with Heightened Long COVID Risk but Prior Immunization is Protective Objectives Patients with autoimmune disease (AD) may be predisposed to Long COVID, yet the impact of primary autoantibody-associated AD and prior immunization remains unclear. Methods...

I thought it would be good to have a thread for this year's Long Covid Awareness Day - March 15, 2026. Please post links for news coverage, advocacy, blog posts, etc.

I don't see a thread for the Long COVID & Post Infectious Syndrome ECHO sessions. If I missed it then please move this post - thanks! The website showing the schedule for monthly sessions - first Tuesday of every month - is here: https://physicians.utah.edu/echo/long-covid Sessions are...

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies [Line breaks added] Abstract SARS-CoV-2 persistence is a proposed driver of Long COVID (LC), but the in-situ relationship between residual viral antigen and immune dysregulation remains...

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients Abstract Chronic persistence of systemic symptoms after recovery from active CoVID-19 has become a significant disease burden, named post-CoVID syndrome...

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19 Abstract Introduction Long-term COVID-19 syndrome (LTCS) or “long COVID” is a debilitating post-viral condition affecting approximately 2%–8% of individuals after SARS-CoV-2 infection. It manifests typically...

Developing a platform protocol for clinical trials evaluating interventions that target proposed mechanisms of Long COVID: RECOVER-VITAL Background Long COVID, the chronic sequela of SARS-CoV-2 infection, has affected millions of people worldwide. However, its pathogenesis and treatment remain...

Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation–a controlled study An unedited version of the manuscript Background Long-COVID remains incompletely understood, particularly regarding the roles of peripheral...

Mesenchymal stromal cell therapy for post-COVID-19 syndrome: associated impact and mechanism Background Post-COVID-19 syndrome (PCS) affects around 10% of individuals who experience SARS-CoV-2 infection worldwide. This four-year follow-up study investigated the long-term impact of mesenchymal...

Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers Highlights • Neuropsychological long COVID i.e. “brain fog” were investigated by biomarkers. • Cognitive impairments related to abnormal rCBF in the occipital lobe. • Psychological symptoms related to...

Distinguishing post-COVID from long-COVID in adults: Development and validation of a biomarker signature using targeted proteomics and machine learning in a cross-sectional observational study Background COVID-19 can have diverse clinical manifestations, ranging from asymptomatic infection to...

Reclaiming health: a qualitative, explorative study of long covid recovery journeys involving mind-body approaches https://www.medrxiv.org/content/10.64898/2026.02.21.26345052v1 Objective This study explored the recovery experiences of individuals who report having (largely) recovered from...

Acute inflammation and fronto-striatal connectivity in the transition from acute to persistent fatigue after mild COVID-19: A longitudinal fMRI study Background Persistent fatigue is one of the most common and disabling sequelae of COVID-19, yet its neurobiological mechanisms remain poorly...