long covid

Fatigue in Long COVID (FALCON) Study registration: https://clinicaltrials.gov/study/NCT07697261 Lead researcher: Jason Busse Long COVID affects about 6 in 100 people after a COVID-19 infection. It can cause ongoing problems like ongoing tiredness, muscle pain, and "brain fog." We know very...

Fatigue after COVID-19 infection is associated with peripheral immunometabolic alterations affecting neuroimmune responses in the hippocampus Abstract Fatigue is a common and disabling symptom reported following SARS-CoV-2 infection, yet the underlying biological mechanisms remain poorly...

SARS-CoV-2 spike-driven reactivation of latent herpesviruses as a mechanistic link to post-viral diseases Jana, Manoj K.; Nora-Krukle, Zaiga; Prusty, Bhupesh K. Significance Persistent symptoms following viral infections are increasingly recognized, yet the biological mechanisms driving...

CD4+ T cell signature in long COVID: insights from an unvaccinated cohort Abstract Objective: The pathogenesis of Long COVID (LC) remains poorly understood, with the analysis of immune responses often obscured by variables such as vaccination and reinfection. This study aimed to determine...

Agreement and reliability between the two-day 6-minute incremental step test and two-day cardiopulmonary exercise test in post COVID-19 condition for assessing post-exertional malaise: The REVEAL-study Abstract Background Post-Exertional Malaise (PEM) is a core symptom of post COVID-19...

Functional outcomes of children after SARS-CoV-2 infection: An EHR-based cohort study Abstract Background Clinical manifestations of the post-acute sequelae of SARS-CoV-2, or long COVID, have been well-described. However, few pediatric studies explore the impact on everyday function. The...

Symptom variation up to two years post-SARS-CoV-2 infection in Children and Young People: results from the Children and young people with Long Covid (CLoCk) study Abstract Background Post Covid-19 Condition (PCC) can fluctuate over time, yet, no in-depth investigation of the heterogeneous PCC...

Astrogliosis Marker [11C]SL25.1188 After COVID-19 With Ongoing Depressive and Cognitive Symptoms Background After acute COVID-19, 5% of people experience persistent depressive symptoms and reduced cognitive function (COVID-DC). Theoretical models propose that astrogliosis is important in long...

Neurological impairment in long COVID: implications for neurodegenerative disease Abstract Background It has been six years since the COVID-19 pandemic and, despite substantial advances in management, the disease sequelae known as long COVID continues to represent a significant medical and...

Abstract: Background Dopaminergic neurons are vulnerable to injury from gliosis and have high density of ACE2 receptors, but the integrity of dopaminergic neurons has not been investigated in long COVID. This study examined whether vesicular monoamine transporter 2 (VMAT2) binding, index of...

Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19: in vivo evidence of structural autonomic dysfunction Highlights • Last evidences support autonomic dysfunction in the pathophysiology of Long COVID-19. • In the gastrointestinal tract vagal innervation plays a role in the...

Low serum selenium combined with SELENOP-autoantibodies are associated with persistent fatigue after SARS-CoV-2 infection Abstract Background Cytokines found during post-acute sequelae after COVID-19 are known to reduce selenoprotein biosynthesis, raising the question whether low selenium...

A Cohort Study on Traditional Chinese Medicine Syndrome Differentiation-based Treatment for Post-COVID-19 Syndrome Abstract Background and objectives Due to the lack of specific Western medicine therapies for post-coronavirus disease 2019 (COVID-19) syndrome in clinical practice, this study...

Enrolling and retaining a representative population in the NIH Researching COVID to Enhance Recovery (RECOVER)-Adult Cohort Abstract Background Vulnerable populations are underrepresented in clinical studies. The design of the national RECOVER-Adult cohort study aimed to over-enroll...

Metformin for fatigue and cognitive dysfunction associated with postCOVID-19 condition and other suspected mitochondrial dysfunction: a case series Stahl, James E. Abstract Background PostCOVID-19 condition (long COVID) is commonly associated with persistent fatigue and cognitive dysfunction...

Prevalence and determinants of long COVID and SARS-CoV-2 reinfection in the Spanish adult population: A nationwide public health survey Abstract Introduction Long COVID is an emerging public health concern with heterogeneous prevalence. Evidence on the impact of reinfection and vaccination...

Dynamic multivariate patterns of brain structure–neuropsychiatric symptom associations in long COVID Abstract Long COVID presents with heterogeneous and persistent neuropsychiatric symptoms, suggesting possible shared neural underpinnings. However, the dynamic brain structure–symptom...

Beyond functional independence: symptom burden and emotional difficulties in pediatric long COVID—a cross-sectional exploratory study Abstract Background: Pediatric Long COVID poses significant challenges to daily functioning, yet its real-world impact remains poorly understood. Standard...

Efficacy and safety of rivaroxaban, colchicine, and famotidine–loratadine with specialist supportive clinical care for fatigue in patients with post-COVID-19 condition in the UK: a multisite, open-label, randomised controlled trial (STIMULATE-ICP consortium) Abstract: Background Post-acute...

Telehealth-Based Ketogenic Metabolic Therapy With Lifestyle Interventions for Post-viral Illness: A Research Brief of Patients’ Experiences Colgan, Dana Dharmakaya; Stadler, Diane D.; Grow, Tabitha; Ruddick, Mary; Weimbs, Thomas; Davenport, Todd E.; Zwickey, Heather Background/Objectives...