long covid

Effects of prolonged SARS-CoV2 spike protein exposure in long COVID and a mouse model of the disease Abstract We addressed the question: can the SARS-CoV2 spike protein persist in ACE2+ endothelia in the CNS/other sites and induce a prolonged microvasculature injury syndrome? People who died...

Multi-omic analysis of post-acute sequelae of COVID-19 (PASC) Abstract Millions of patients surviving COVID-19 infection develop post-acute sequelae of COVID-19 (PASC), a debilitating condition that severely disrupts quality of life. Limited data exists on PASC patient peripheral blood...

Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review Negm, Akram; Stolz, Maike; Krauth, Christian Objective To evaluate supervised physical, psycho-logical, and alternative non-pharmacological interventions for improving...

Persistent Cognitive Vulnerability After COVID-19 in Older Adults: Longitudinal Clinical Trajectories and Multi-Cohort Transcriptomic Evidence Lara, Maximiliano Correa; Hernandez, Erika Martinez Background Older adults frequently experience persistent cognitive impairment after COVID-19, yet...

Obstructive sleep apnea is frequent in patients with Long COVID fatigue but is not significantly associated with alterations of quality of life and cognition Abstract Neurologic manifestations of Long COVID, also called post-acute sequelae of SARS-CoV-2 infection (PASC), include fatigue...

Randomized controlled trial of pirfenidone XR for patients with COVID-19 and exploration of effects on long-COVID incidence Abstract Objective Evaluate safety and efficacy of extended-release pirfenidone (pirfenidone-XR), an anti-inflammatory and anti-fibrotic agent, as an early treatment for...

Long-term episodic memory alterations and the role of perceived stress in post-COVID-19 condition Abstract Post-COVID-19 condition (PCC) is frequently associated with cognitive impairments, but the integrity of long-term episodic memory remains poorly understood. This study examined...

Long COVID and financial hardships among workers: Evidence from the California Health Interview Survey, 2022-2023 Garvey, Kathleen; Wambui, David; Vergara, Ximena Abstract Objective: We used California Health Interview Survey (CHIS) data to examine relationships between long COVID and...

Abstract Background: Long COVID continues to burden a significant percentage of the population with debilitating symp-toms, including cognitive impairment ("brain fog"), fatigue, post-exertional malaise (PEM), and sleep disturbance, contributing to a poor quality of life (QoL). Evidence...

Inflammatory and immunologic analysis of bronchoalveolar lavage from patients with post-COVID-19 lung disease Abstract Rationale: Infection with SARS-CoV-2 frequently leads to persistent pulmonary symptoms and radiographic abnormalities, of which several clinical phenotypes have been...

Neurological, Neuromuscular, and Autonomic Manifestations of COVID-19: A Retrospective Study Abstract Background Neurovascular, neuromuscular, and autonomic complications of COVID-19 have rarely been characterized within a single cohort. Objective To compare the clinical, electrodiagnostic...

Simultaneous determination of serotonin and its precursor tryptophan in small volumes of human serum using HPLC-ECD Abstract Serotonin (5-HT) is not only a key neurotransmitter in the brain but also plays an important role in peripheral tissues e.g. in the gastrointestinal (GI) tract. The...

Persistently activated virus-specific CD8 T cells indicate antigen-driven immune aberrations in long COVID Abstract Long COVID (LC) affects millions of people worldwide, yet its driving mechanisms remain incompletely defined and no treatment has been approved. Persistence of SARS-CoV-2 and...

Dysregulated complement activation in COVID-19: The Role of Soluble Complement Inhibitors Abstract In viral infections, complement activation can contribute to viral clearance, but excessive activation, as observed in severe COVID-19, may drive immunopathology. While much is known about...

Ein Einblick in die Long/Post COVID-Versorgungslage in Deutschland – ein Rapid Scoping Review Machine translation: Abstract Background Long/Post COVID and related conditions, such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS), and...

Integrative perspectives on electroacupuncture modulation of vagal–cholinergic and neuro–immune–metabolic regulation in long COVID Wang, Liwen; Hu, Xiaoyang; Yan, Dongning Abstract Long COVID is increasingly recognized as a multisystem condition involving persistent inflammation, autonomic...

Long COVID is associated with lipoxygenase-catalyzed metabolism of essential polyunsaturated fatty acids Summary Long COVID (LC) represents a failure of healthy resolution mechanisms for inflammation after SARS-CoV-2 infection. Dietary essential polyunsaturated fatty acids (PUFAs) and their...

Self-Rated Health and Persistent Symptoms Among Adults Reporting Previous SARS-CoV-2 Infection: A Cross-Sectional Study Abstract Background/Objectives: Health self-assessment captures perceived physical and psychological well-being. This study described current and recalled pre-infection...

Experiences of Inspiratory Muscle Training and Physical Exercise in Adults with Post-COVID-19 Condition and Inspiratory Muscle Weakness: A Qualitative Study Abstract Background/Objectives: Inspiratory muscle training and physical exercise may benefit individuals with post-COVID-19 condition...

Four-Year Longitudinal Phenotyping of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC): A Single-Centre Cohort Study Sárközi, Anna Teréz; Tornyi, Ilona; Horváth, Ildikó Abstract Background: Although an increasing number of studies have reported 2- and 3-year outcomes of post-acute sequelae...