long covid

Microvascular Dysfunction and Redox Imbalance in Long COVID ABSTRACT Objective Endothelial and microvascular dysfunction are key features of Long COVID. Disturbances in cellular redox balance, reflected by altered nicotinamide adenine dinucleotide (NAD+/NADH) dynamics, may underlie vascular...

Clinical Phenotypes of Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection: A Longitudinal Cohort Study from Karachi, Pakistan Abstract Post Acute Sequelae of SARS CoV 2 infection, or PASC, is an emerging public health concern. Longitudinal data from South Asia remain limited and the burden...

Kinetics of the PASC Index in Long COVID Abstract Background The post‑acute sequelae of SARS‑CoV‑2 infection (PASC, “Long COVID”) remain difficult to evaluate because standardized diagnostic tools are limited. We applied the recently proposed PASC index (score ≥ 12) to describe the 12‑month...

A brief report: absence of elevated circulating NETosis markers in long-term long COVID Background Neutrophil extracellular trap (NET) formation (NETosis) has been proposed as a contributor to the pathophysiology of Long COVID (LC). However, it remains unclear whether markers of systemic...

Serum Cu/Zn ratio is significantly associated with long COVID Abstract Since the coronavirus disease 2019 (COVID-19) pandemic, many people have been affected by COVID-19. However, at present, neither reliable predictors of long COVID nor effective treatments are widely established. The aim...

Long COVID and risk of incident cardiovascular disease: a prospective cohort study using the Multimorbidity Integrated Registry Across Care Levels in Stockholm (MIRACLE-S) cohort Summary Background Long COVID has emerged as a global health challenge, with increasing evidence of cardiovascular...

Association between physical activity before SARS-CoV-2 infection and functional disability 24 months after COVID-19: findings from the SulCOVID-19 longitudinal study Abstract Background Individuals diagnosed with coronavirus disease 2019 (COVID-19), even those with mild illness, report...

Effects of Viusid in Long COVID: A Randomized Double-Blind Placebo-Controlled Trial Abstract Introduction: Long COVID syndrome (LCS) is characterized by persistent neurological, respiratory, and systemic symptoms following SARS-CoV-2 infection, with limited effective treatments available...

Note: This is Belton's self case study, which was published the year before the brain retraining feasibility study 'I want everyone to be on it..." being discussed here. Health Expect. 2025 Apr 23;28(3):e70227. doi: 10.1111/hex.70227 ‘The Second Arrow’: A Collaborative Autoethnographic...

HSP60 and SARS-CoV-2: Les Liaisons Dangereuses Simple Summary This review examines the role of heat shock protein 60 (Hsp60) in COVID-19, highlighting its impact on immune modulation, inflammation, and endothelial dysfunction. Hsp60, a chaperone protein essential for protein folding and...

The silent infection load: How lifelong asymptomatic infections may contribute to inflammaging as an evolutionary trade-off of longevity Cossarizza, Andrea; Poli, Guido; Clerici, Mario Highlights Chronic EBV, CMV, and SARS-CoV-2 can shape lifelong immune activation. Subclinical/chronic...

Improvement of post-COVID-19 vaccination dysautonomia with GLP-1 receptor agonist Abstract Vasovagal syncope (VVS) is the most common form of cardiovascular dysautonomia that has multiple etiologies. Post-vaccination dysautonomia, in the form of VVS and postural orthostatic tachycardia...

Prevalence and predictors of prescription opioids among United States adults with long COVID Axon, David Rhys; Fenwick, Stephanie B. Abstract Long COVID may occur in some patients after contracting COVID-19. Opioids are employed as one of many management and treatment strategies for this...

Targeting the JAK/STAT pathway in chronic viral infections: opportunities and challenges for immunomodulation Abstract The discovery of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway as a key regulator of immune function and inflammation led to the...

Serum Proteomic Profiling Reveals Renin-Associated Immune and Cytoskeletal Dysregulation in Post-COVID-19 Condition Patients with Secondary Adrenal Insufficiency Abstract Post-COVID-19 condition (PCC) with secondary adrenal insufficiency (SAI) involves multiorgan dysfunction, potentially...

From HIV to SARS-CoV-2 associated neurological disorder (“HAND” to “SAND”): Viral infection as a “time-bomb“ for the aging brain Millan, Mark J. Highlights SARS-CoV-2 infections frequently trigger a delayed, multi-organ syndrome called Long Covid. A subset of symptoms, including cognitive...

Impaired auditory sensory gating as a neurophysiological correlate of cognitive fatigue in long COVID. Mischke, Magdalena; Zaehle, Tino Objective Fatigue is among the most disabling symptoms across neurological and postinfectious conditions and is a defining feature of long COVID, yet...

Registered interventional trials fail to cover patient-prioritised treatments in Post-COVID condition (PCC) Purpose Despite the substantial health and socioeconomic burden of Post-COVID condition (PCC), no disease-modifying therapy has been established, largely because of clinical...

A thread to collect information and trial results to do with antivirals and LC, and discuss the covid-19 viral persistence hypothesis. Split from: Antivirals as an ME/CFS treatment (e.g. valacyclovir, valgancyclovir, amantadine) Null result for paxlovid in a decent sized blinded long covid...

I thought it would be good to start a thread for news and updates from Jarred Younger and his "Neuroinflammation, Pain, and Fatigue Laboratory" at UAB since he is active on Facebook and has a newsletter Link to Facebook page...