long covid

Abstract: Background Dopaminergic neurons are vulnerable to injury from gliosis and have high density of ACE2 receptors, but the integrity of dopaminergic neurons has not been investigated in long COVID. This study examined whether vesicular monoamine transporter 2 (VMAT2) binding, index of...

Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19: in vivo evidence of structural autonomic dysfunction Highlights • Last evidences support autonomic dysfunction in the pathophysiology of Long COVID-19. • In the gastrointestinal tract vagal innervation plays a role in the...

Low serum selenium combined with SELENOP-autoantibodies are associated with persistent fatigue after SARS-CoV-2 infection Abstract Background Cytokines found during post-acute sequelae after COVID-19 are known to reduce selenoprotein biosynthesis, raising the question whether low selenium...

A Cohort Study on Traditional Chinese Medicine Syndrome Differentiation-based Treatment for Post-COVID-19 Syndrome Abstract Background and objectives Due to the lack of specific Western medicine therapies for post-coronavirus disease 2019 (COVID-19) syndrome in clinical practice, this study...

Enrolling and retaining a representative population in the NIH Researching COVID to Enhance Recovery (RECOVER)-Adult Cohort Abstract Background Vulnerable populations are underrepresented in clinical studies. The design of the national RECOVER-Adult cohort study aimed to over-enroll...

Metformin for fatigue and cognitive dysfunction associated with postCOVID-19 condition and other suspected mitochondrial dysfunction: a case series Stahl, James E. Abstract Background PostCOVID-19 condition (long COVID) is commonly associated with persistent fatigue and cognitive dysfunction...

Prevalence and determinants of long COVID and SARS-CoV-2 reinfection in the Spanish adult population: A nationwide public health survey Abstract Introduction Long COVID is an emerging public health concern with heterogeneous prevalence. Evidence on the impact of reinfection and vaccination...

Dynamic multivariate patterns of brain structure–neuropsychiatric symptom associations in long COVID Abstract Long COVID presents with heterogeneous and persistent neuropsychiatric symptoms, suggesting possible shared neural underpinnings. However, the dynamic brain structure–symptom...

Beyond functional independence: symptom burden and emotional difficulties in pediatric long COVID—a cross-sectional exploratory study Abstract Background: Pediatric Long COVID poses significant challenges to daily functioning, yet its real-world impact remains poorly understood. Standard...

Efficacy and safety of rivaroxaban, colchicine, and famotidine–loratadine with specialist supportive clinical care for fatigue in patients with post-COVID-19 condition in the UK: a multisite, open-label, randomised controlled trial (STIMULATE-ICP consortium) Abstract: Background Post-acute...

Telehealth-Based Ketogenic Metabolic Therapy With Lifestyle Interventions for Post-viral Illness: A Research Brief of Patients’ Experiences Colgan, Dana Dharmakaya; Stadler, Diane D.; Grow, Tabitha; Ruddick, Mary; Weimbs, Thomas; Davenport, Todd E.; Zwickey, Heather Background/Objectives...

Clinical neuropsychological evaluation of patients referred from a post-COVID subspeciality clinic Objective To describe neuropsychological assessment findings of patients referred from a post-COVID subspecialty clinic. Methods Clinical data were examined for 54 patients referred between...

Black Patients Underdiagnosed With Long COVID In The US Compared With White Patients Abstract Long COVID has debilitating effects but is inconsistently diagnosed because of subjective criteria, limited treatments, and variations in health care access. We analyzed electronic health records...

Chronic stress primes TLR3-mediated systemic inflammation to produce persistent post-viral fatigue syndrome-like symptoms in mice Highlights • Chronic stress in combination with poly I:C produces persistent multi-domain PVFS-like symptoms in mice. • Minocycline attenuates fatigue...

Implications of RNA virus persistence for post-acute sequelae and chronic inflammatory syndromes Vidal, Daniela; Castro, Ítalo de Araújo; López, Carolina B. Abstract Viral persistence refers to the ability of a virus to remain in its host for an extended period. Although most non-retroviral...

Long-term trajectories of social adjustment and emotional/behavioral problems in pediatric post-acute COVID-19 Abstract COVID-19 has been associated with adverse mental health outcomes in children. However, evidence regarding the long-term trajectories of post-acute symptoms remains limited...

Post-COVID-19 immune dysregulation and autoimmune sequelae Abdel-Moneim, Ahmed S.; Al-Balushi, Mohammad S.; Al-Jabri, Ali A. Highlights SARS-CoV-2 infection can induce persistent immune dysregulation : hyperinflammation, lymphopenia, and innate–adaptive imbalance. Molecular mimicry, bystander...

Dissociation Between Peripheral Muscle Strength and Exercise Capacity in Symptomatic Post‐COVID‐19 Individuals: Implications for Musculoskeletal Rehabilitation ABSTRACT Introduction Infection with SARS-CoV-2 may result in persistent functional impairment after the acute phase of the disease...

Association between corticosteroid therapy during acute COVID-19 and Long COVID symptoms: a propensity score overlap-weighted analysis Highlights • Long-term effects of acute-phase corticosteroids remain uncertain. • Overlap weighting was applied in a multicenter COVID-19 cohort. •...

Association of kynurenine metabolites with cognitive and psychological symptoms in post COVID-19 condition: A case-control study Background Cognitive dysfunction and psychological symptoms, including depression and anxiety, are commonly observed in chronic post COVID condition (PCC)...