lupus

Diagnostic overshadowing in systemic lupus erythematosus (SLE): A qualitative study Rupert Harwood, Chris Wincup, David D’Cruz, and Melanie Sloan [Line breaks added] Objectives SLE diagnostic journeys can be protracted, with negative impacts on long-term health. This study explored the role...

Posting several links exploring temporal dynamics between interferon, autoantibodies, and autoimmune diseases (primarily lupus). (Review) Emerging concepts of type I interferons in SLE pathogenesis and therapy Note: SLE = systemic lupus erythematosus Links to references are active in the...

Simple blood test offers new hope to lupus patients

Ignored, Dismissed, and Minimized: Understanding the Harmful Consequences of Invalidation in Health Care—A Systematic Meta-Synthesis of Qualitative Research Allyson C. Bontempo, John M. Bontempo, Paul R. Duberstein [Line breaks added] Abstract The upsurge in the prevalence of contested...

I’ve been wondering whether it’s helpful to compare how cognitive behavioral therapy (CBT) is used in systemic lupus erythematosus (SLE) and in ME/CFS. Both are complex, multifactorial chronic illnesses. Adverse childhood experiences are also thought to increase the risk of developing SLE, and...

Correlation of Interferons and Autoimmune Aspects in Long COVID-19 Patients Fumiyuki Hattori, Junji Nishiyama, Hideaki Hasuo [Line break added] Abstract Long COVID, or post-acute sequelae of COVID-19 (PASC), represents a major global health challenge, with its underlying mechanisms remaining...

Exploring the shared mechanism of fatigue between systemic lupus erythematosus and myalgic encephalomyelitis/chronic fatigue syndrome: monocytic dysregulation and drug repurposing Daisi Zheng, Xiaolong Li, Qingmiao Zhu, Zhiyan Huang, Peicheng Wang, Ting Zhao [Provisionally accepted] Edit: Now...

Epstein–Barr virus as a potentiator of autoimmune diseases William H. Robinson, Shady Younis, …Tobias V. Lanz Show authors Nature Reviews Rheumatology (2024)Cite this article Metricsdetails Abstract The Epstein–Barr virus (EBV) is epidemiologically associated with development of autoimmune...

Interferon gene expression declines over time post-COVID infection and in long COVID patients A. Gómez-Carballa; S. Pischedda; J. Pardo-Seco; J. Gómez-Rial; F. Martinón-Torres; A. Salas BACKGROUND Interferons (IFNs) represent a first-line defense against viruses and other pathogens. It has been...

Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus Law, Calvin; Wacleche, Vanessa Sue; Cao, Ye; Pillai, Arundhati; Sowerby, John; Hancock, Brandon; Horisberger, Alice; Bracero, Sabrina; Skidanova, Viktoriya; Li, Zhihan; Adejoorin, Ifeoluwakiisi; Dillon, Eilish; Benque, Isaac...

Researchers found medication that controls blood sugar levels in type 2 diabetes can also help patients with certain auto-immune diseases such as Lupus and arthritis Drug used by millions for common condition could end pain for arthritis sufferers - Mirror Online

Objective Whereas genetic susceptibility for systemic lupus erythematosus (SLE) has been well explored, the triggers for clinical disease flares remain elusive. To investigate relationships between microbiota community resilience and disease activity, we performed the first longitudinal...

Published: 19 April 2023 Authors: Frade S, O'Neill S, Greene D, Nutter E, Cameron M https://www.cochrane.org/CD014816/MUSKEL_what-are-benefits-and-risks-exercise-people-systemic-lupus-erythematosus full review here...

Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus Abstract Objectives To analyse whether reported fatigue, one of the most challenging manifestations of systemic lupus...

I don't know if this has been posted elsewhere but I thought it was very interesting. I wonder if something like this might end up being helpful for a subset of pwME... https://www.theguardian.com/science/2022/sep/15/scientists-hail-autoimmune-disease-therapy-breakthrough-car-t-cell-lupus "In...

2022 has been an auspicious year for systemic lupus erythematosus (SLE). In February, the interferon receptor inhibitor anifrolumab became only the second targeted agent to be approved in Europe for treatment of SLE in more than six decades. A few months later, a 7-year-old Spanish girl who...

Mahieu MA, Ahn GE, Chmiel JS, Dunlop DD, Helenowski IB, Semanik P, Song J, Yount S, Chang RW, Ramsey-Goldman R. Fatigue, patient reported outcomes, and objective measurement of physical activity in systemic lupus erythematosus. Lupus. 2016 Oct;25(11):1190-9. doi: 10.1177/0961203316631632. Epub...

Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus Maria Tokuyama, Bronwyn M. Gunn, Arvind Venkataraman, Yong Kong, Insoo Kang, Tasfia Rakib, Michael J. Townsend, Karen H. Costenbader, Galit Alter and Akiko Iwasaki Journal of...

Abstract. Estrogen-related receptor gamma (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls regulatory T cells (Treg) through mitochondria homeostasis. Esrrg deficiency impaired the maintenance and function of Treg cells...

Summary Daratumumab, a human monoclonal antibody that targets CD38, depletes plasma cells and is approved for the treatment of multiple myeloma. Long-lived plasma cells are implicated in the pathogenesis of systemic lupus erythematosus because they secrete autoantibodies, but they are...