microglia

Full title: Chronic inflammation, neuroglia dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome Highlights Plasmalogens (Pls) are lipids containing a...

Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms Diana Romenskaja; Ugne Jonavice; Augustas Pivoriunas Autophagy dysfunction has been closely related with pathogenesis of many neurodegenerative diseases and therefore represents a potential...

:emoji_warning: At this point it's still a preprint. Abstract: As most of you know, in the 80s researchers were excited about several (and separate) finds of retroviral activity in what we now call ME/CFS patients. The main researcher was Elaine DeFreitas, whose finds got dismissed by UK...

The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways O'Connor, Jennifer L.; Nissen, Jillian C. Microglia are the primary immunocompetent cells of the central nervous system (CNS). Their ability to survey, assess and respond to perturbations in their local...

The central nervous systems proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2 In COVID-19 neurological alterations are noticed during the systemic viral infection. Various pathophysiological mechanisms on the central nervous system (CNS) have been suggested in...

Microglia regulate central nervous system myelin growth and integrity McNamara, Niamh B, Munro, David A. D, Bestard-Cuche, Nadine, Uyeda, Akiko, Bogie, Jeroen F. J, Hoffmann, Alana, Holloway, Rebecca K, Molina-Gonzalez, Irene, Askew, Katharine E, Mitchell, Stephen, Mungall, William, Dodds...

Published version linked in a later post ***** Preprint Choroid Plexus calcification correlates with cortical microglial activation in humans: a multimodal PET, CT, MRI study Tracy Butler, X. Hugh Wang, Gloria C. Chiang, Yi Li, Liangdong Zhou, Ke Xi, NimmiWickramasuriya, Emily Tanzi, Edward...

Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study Etter MM, Martins TA, Kulsvehagen L, Pössnecker E, Duchemin W, Hogan S, Sanabria-Diaz G, Müller J, Chiappini A, Rychen J, Eberhard N, Guzman R, Mariani L...

Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV‐2 Artem Pliss, Andrey N. Kuzmin, Paras N. Prasad, Supriya D. Mahajan The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is...

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction Fuyuko Takata, Shinsuke Nakagawa, Junichi Matsumoto, Shinya Dohgu Neuroinflammation is...

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain Preprint Abstract Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in...

Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena, Mark Drakesmith, Kristin Koller, Derek K Jones, Santiago Canals, Silvia De Santis While glia are increasingly implicated in the pathophysiology of...

https://osf.io/ef3n4/ The newsbrief posting reminded me that this paper wasn't mentioned. I think it may be a pretty important hypothesis for ME's root cause. It fits what I believe is the root cause of ME: that neuroglia are involved. I'm not sure whether there are any ME symptoms that...

For the abstract of the published paper, go to post #9 Preprint Abstract Myalgic Encephalomyelitis and chronic fatigue syndrome is a multisystem illness characterized with extreme muscle fatigue associated with pain, neurocognitive impairment, and chronic inflammation. Despite intense...

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? Theoharis C. Theoharides Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine Abstract SARS-CoV-2 infects cells via its spike protein binding to its...

Full title: Chronic cerebral aspects of long COVID, post-stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic Abstract The chronic neurological aspects of traumatic brain injury, post-stroke syndromes, long COVID-19, persistent Lyme disease, and...

Brief Summary: The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with...

Comer Ashley L., Carrier Micaël, Tremblay Marie-Ève, Cruz-Martín Alberto (2020), The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation, Frontiers in Cellular Neuroscience 14 (2020), DOI...

In mice. https://www.biorxiv.org/content/10.1101/2021.08.02.454769v1 TL;DR: microglia can influence cerebral vasculature. (Paragraphs mine for legibility) Microglia are brain-resident immune cells with a repertoire of functions in the developing, mature and pathological brain. Their...

Abstract During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, neurological symptoms increasingly moved into the focus of interest. In this prospective cohort study, we assessed neurological and cognitive symptoms in hospitalized coronavirus disease-19 (COVID-19)...