microglia

  1. rvallee

    Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions, 2021

    Performed detailed molecular and spatial analysis of the COVID-19 brain immune response Pathognomonic microglial nodules and T cell infiltration are present in COVID-19 brains Altered microglia-T cell interactions correlate with systemic measures of inflammation Vascular leakage is linked with...
  2. M

    The Pathogenesis of Long-Term Neuropsychiatric COVID-19 and the Role of Microglia, Mitochondria, and Persistent Neuroinflammation, 2021, Stefano et al

    Full title: Editorial: The Pathogenesis of Long-Term Neuropsychiatric COVID-19 and the Role of Microglia, Mitochondria, and Persistent Neuroinflammation: A Hypothesis (2021) Stefano et al. Abstract: Persistent comorbidities occur in patients who initially recover from acute coronavirus disease...
    • Milo
    • Thread
    • long covid microglia mitochondria neuroinflammation
    • Replies: 8
    • Forum: Long Covid research
  3. rvallee

    COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital, 2021, Thakur et al

    (Line breaks mine for legibility) Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the clinical, neuropathological, and molecular findings...
  4. leokitten

    Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders (2019) Werry et al

    An interesting read given the past TSPO-PET neuroinflammation studies on ME using first generation [11C]PK-11195 and now more recently second generation [11C]DPA-713, the pros/cons and limitations of these radioligands, and the development of novel third generation ligands. Recent Developments...
  5. leokitten

    An Inflammation-Centric View of Neurological Disease: Beyond the Neuron (2018) Skaper et al

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/ Abstract:
  6. Andy

    Brain astrocytes & microglia express functional MR1 molecules that present microbial antigens to ... (MAIT) cells, 2020, Priya et al

    Full title: Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells Paywall, https://www.jni-journal.com/article/S0165-5728(20)30689-5/fulltext Sci hub, https://sci-hub.se/10.1016/j.jneuroim.2020.577428
  7. J

    BDNF reverses aging-related microglial activation, Wu et al. 2020

    https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01887-1
  8. J

    Regional microglial activation in the substantia nigra is linked with fatigue in MS, 2020, Singhal et al.

    https://nn.neurology.org/content/7/5/e854 Popular article here Hunting for a "Hidden Pathology": Why Is Fatigue So Debilitating in Multiple Sclerosis? https://www.technologynetworks.com/neuroscience/news/hunting-for-a-hidden-pathology-why-is-fatigue-so-debilitating-in-multiple-sclerosis-339120
  9. Andy

    Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma, 2020, Gensel et al

    Open access, https://www.sciencedirect.com/science/article/pii/S0014488620301412
  10. Andy

    Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation, 2020, Bhargarva et al

    Open access, https://www.jci.org/articles/view/129401
  11. stuck

    Dual microglia effects on blood brain barrier permeability induced by systemic inflammation, 2019, Hiroaki Wake et al.

    Moderator note: Copied from this thread: "Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia... van Campen et al, 2020 _____________________________ There is this new article but sorry if it is old study news, I'm new to...
  12. Snowdrop

    Learning from tragedy--a baby lacking critical brain cells and a medical detective story (2019)

    This is a story about neurology that I thought might be of general interest. I found this on CBC's Quirks and Quarks: Before he was born, his parents knew their boy was in trouble. That was clear from what their doctors' saw in their baby's ultrasound. And tragically, the boy died when he was...
  13. Andy

    Pain and fatigue – a systematic review, 2019, Conrad et al

    Open access in German at https://www.vr-elibrary.de/doi/10.13109/zptm.2018.64.4.365#.XIPVq9EuDUI
  14. Sly Saint

    Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their Comorbidities - (2019) Filho, Macedo,Freitas de Lucena,Maes

    This version is not peer-reviewed https://www.preprints.org/manuscript/201902.0029/v1...
    • Sly Saint
    • Thread
    • 2019 depression fatigue filho macedo maes me/cfs microglia paper
    • Replies: 5
    • Forum: ME/CFS research
  15. leokitten

    The antiviral drug ganciclovir does not inhibit microglial proliferation and activation (2015) Skripuletz, et al.

    I took Valcyte for 2 1/2 years. I had suspected infectious onset based on initial fever and symptoms, as well as chronically very high EBV, CMV, HHV-6 antibody titers. Valcyte didn’t have any effect on my ME, though I was working full-time and push-crashing all the time. Valcyte also had this...
  16. Indigophoton

    Tracking peripheral immune cell infiltration of the brain in ME

    Very interesting sounding project from Jarred Younger, http://www.meresearch.org.uk/our-research/ongoing-studies/immune-cell-infiltration/
    • Indigophoton
    • Thread
    • immunology jarred younger microglia neuroinflammation neurology t cells
    • Replies: 1
    • Forum: ME/CFS research
  17. Indigophoton

    How the gut influences neurologic disease

    Possibly relevant to ME given the potential involvement of both microglia in the brain and the microbiome in the illness. The article, https://medicalxpress.com/news/2018-05-gut-neurologic-disease.amp https://www.nature.com/articles/s41586-018-0119-x
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