microglia

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction Fuyuko Takata, Shinsuke Nakagawa, Junichi Matsumoto, Shinya Dohgu Neuroinflammation is...

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain Preprint Abstract Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in...

Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena, Mark Drakesmith, Kristin Koller, Derek K Jones, Santiago Canals, Silvia De Santis While glia are increasingly implicated in the pathophysiology of...

https://osf.io/ef3n4/ The newsbrief posting reminded me that this paper wasn't mentioned. I think it may be a pretty important hypothesis for ME's root cause. It fits what I believe is the root cause of ME: that neuroglia are involved. I'm not sure whether there are any ME symptoms that...

For the abstract of the published paper, go to post #9 Preprint Abstract Myalgic Encephalomyelitis and chronic fatigue syndrome is a multisystem illness characterized with extreme muscle fatigue associated with pain, neurocognitive impairment, and chronic inflammation. Despite intense...

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? Theoharis C. Theoharides Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine Abstract SARS-CoV-2 infects cells via its spike protein binding to its...

Full title: Chronic cerebral aspects of long COVID, post-stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic Abstract The chronic neurological aspects of traumatic brain injury, post-stroke syndromes, long COVID-19, persistent Lyme disease, and...

Brief Summary: The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with...

Comer Ashley L., Carrier Micaël, Tremblay Marie-Ève, Cruz-Martín Alberto (2020), The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation, Frontiers in Cellular Neuroscience 14 (2020), DOI...

In mice. https://www.biorxiv.org/content/10.1101/2021.08.02.454769v1 TL;DR: microglia can influence cerebral vasculature. (Paragraphs mine for legibility) Microglia are brain-resident immune cells with a repertoire of functions in the developing, mature and pathological brain. Their...

Abstract During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, neurological symptoms increasingly moved into the focus of interest. In this prospective cohort study, we assessed neurological and cognitive symptoms in hospitalized coronavirus disease-19 (COVID-19)...

Performed detailed molecular and spatial analysis of the COVID-19 brain immune response Pathognomonic microglial nodules and T cell infiltration are present in COVID-19 brains Altered microglia-T cell interactions correlate with systemic measures of inflammation Vascular leakage is linked with...

Full title: Editorial: The Pathogenesis of Long-Term Neuropsychiatric COVID-19 and the Role of Microglia, Mitochondria, and Persistent Neuroinflammation: A Hypothesis (2021) Stefano et al. Abstract: Persistent comorbidities occur in patients who initially recover from acute coronavirus disease...

(Line breaks mine for legibility) Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the clinical, neuropathological, and molecular findings...

An interesting read given the past TSPO-PET neuroinflammation studies on ME using first generation [11C]PK-11195 and now more recently second generation [11C]DPA-713, the pros/cons and limitations of these radioligands, and the development of novel third generation ligands. Recent Developments...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/ Abstract:

Full title: Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells Paywall, https://www.jni-journal.com/article/S0165-5728(20)30689-5/fulltext Sci hub, https://sci-hub.se/10.1016/j.jneuroim.2020.577428

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01887-1

https://nn.neurology.org/content/7/5/e854 Popular article here Hunting for a "Hidden Pathology": Why Is Fatigue So Debilitating in Multiple Sclerosis? https://www.technologynetworks.com/neuroscience/news/hunting-for-a-hidden-pathology-why-is-fatigue-so-debilitating-in-multiple-sclerosis-339120

Open access, https://www.sciencedirect.com/science/article/pii/S0014488620301412