monocytes

Amplification of select autonomous HERV loci and surrounding host gene transcription in monocytes from patients with post-acute sequelae of COVID-19 Hyunmin Koo, Casey D. Morrow [Line breaks added] Background The human genome contains approximately 3,200 near full-length autonomous human...

Detection of S1 spike protein in CD16+ monocytes up to 245 days in SARS-CoV-2-negative post-COVID-19 vaccine syndrome PCVS individuals Bruce K. Patterson; Ram Yogendra; Edgar B. Francisco; Jose Guevara-Coto; Emily Long; Amruta Pise; Eric Osgood; John Bream; Mark Kreimer; Devon Jeffers...

Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications Semo, Dilvin; Shomanova, Zornitsa; Sindermann, Jürgen; Mohr, Michael; Evers, Georg; Motloch, Lukas J.; Reinecke, Holger; Godfrey, Rinesh; Pistulli, Rudin Cardiovascular...

368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection Giovanni Berardi, Adam Janowski, Samuel McNally, Gregorius Bernhard, Alpana Garg, Kathleen Sluka Abstract Individuals with...

Persistent immune dysregulation and metabolic alterations following SARS-CoV-2 infection Silvia Lucena Lage; Katherine Bricker-Holt; Joseph M. Rocco; Adam Rupert; Frank X. Donovan; Yevgeniya A. Abramzon; Settara C. Chandrasekharappa; Colton McNinch; Logan Cook; Eduardo Pinheiro Amaral; Gabriel...

SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles Sara Bachiller, Joana Vitalle, Lluís Camprubí-Ferrer, Manuel García, Isabel Gallego, Marina López-García, María Isabel Galvá, Julio Cañizares, Inmaculada Rivas-Jeremías, María Díaz-Mateos, Carmen Gasca-Capote...

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...

Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing Marta Līva Spriņģe; Kristīne Vaivode; Rihards Saksis; Nineļa Miriama Vainšeļbauma; Laura Ansone; Monta Brīvība; Helvijs Niedra; Vita Rovite Long-COVID affects at least 10% of COVID-19...

340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms Thomas K. Awamura, Stefanos Giannakopoulos, Dominic C. Chow, Cecilia M. Shikuma, Gehan Devendra, Vedbar Khadka, Juwon Park Background As the number of COVID-19 survivors amongst the global population continues to rise, the...

Abstract COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with...

Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID Olivares-Martínez, Elizabeth; Hernández-Ramírez, Diego Francisco; Núñez-Álvarez, Carlos Alberto; Meza-Sánchez, David Eduardo; Chapa, Mónica...

Identifying Neuro-inflammatory Biomarkers of Generalized Anxiety Disorder from Lymphocyte Subsets based on machine learning approaches Jingjing Lu, Weiwei Liang, Lijun Cui, Shaoqi Mou, Xuedan Pei, Xinhua Shen, Zhongxia Shen, Ping Shen Introduction Activation of the inflammatory response system...

Identification of an immunological signature of long COVID syndrome Guerrera, Gisella; Sambucci, Manolo; Timperi, Eleonora; Picozza, Mario; Misiti, Andrea; Placido, Roberta; Corbisiero, Silvia; D’Orso, Silvia; Termine, Andrea; Fabrizio, Carlo; Gargano, Francesca; Eleuteri, Sharon; Marchioni...

Abstract: Post-COVID syndrome (PCS) has emerged as a significant health concern with persisting symptoms. A subset of PCS patients develops severe myalgic encephalomyelitis/chronic fatigue syndrome (pcME/CFS). Dysregulated autoantibodies (AABs) have been implicated in PCS, contributing to immune...

Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure Mohammad Saleem; Luul A. Aden; Ashley L. Mutchler; Chitra Basu; Lale A. Ertuglu; Quanhu Sheng; Niki Penner; Anna R. Hemnes; Jennifer H. Park; Jeanne A. Ishimwe; Cheryl L. Laffer; Fernando Elijovich...

Myocardial infarction augments sleep to limit cardiac inflammation and damage Huynh, Pacific et 36 al. Sleep is integral to cardiovascular health. Yet, the circuits that connect cardiovascular pathology and sleep are incompletely understood. It remains unclear whether cardiac injury influences...

Nuclear factor kappa-B cell NF-κB, interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection Savitz; McKinney; Meier; Zheng; Ford; Yolken; Teague; Cole Altered activity of major immunoregulatory pathways has...

Abstract Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...

Type I Interferonopathy among Non-Elderly Female Patients with Post-Acute Sequelae of COVID-19 Xu, Donghua; Qin, Xuebin The pathophysiological mechanisms of the post-acute sequelae of COVID-19 (PASC) remain unclear. Sex differences not only exist in the disease severity of acute SARS-CoV-2...

Immune system adaptation during gender-affirming testosterone treatment Lakshmikanth, Tadepally; Consiglio, Camila; Sardh, Fabian; Forlin, Rikard; Wang, Jun; Tan, Ziyang; Barcenilla, Hugo; Rodriguez, Lucie; Sugrue, Jamie; Noori, Peri; Ivanchenko, Margarita; Piñero Páez, Laura; Gonzalez, Laura...