monocytes

LDLR-OPN Interaction Drives COVID-19 Myocarditis Through Monocyte Recruitment COVID-19–associated myocarditis is marked by macrophage-rich inflammation and adverse cardiac outcomes, yet its mechanisms remain unclear. We developed a reproducible BSL-2 mouse model by combining cardiac-specific...

Intracellular microbial shifts during COVID-19 infection and longitudinal recovery revealed by single-cell RNA sequencing Host-microbe dynamics during SARS-CoV-2 Omicron variant infection and recovery remain poorly understood, particularly regarding intracellular microbial communities in...

Abstract The COVID-19 pandemic has infected more than 778 million people worldwide. Roughly 7% of these patients progress to Long COVID (LC), suffering from persistent symptoms and cognitive impairment well past the acute stage. As the mechanisms of LC remain elusive, we utilized single-cell...

Monocyte Oxidative Stress Underlies Persistent Immune Activation in Long-COVID Postural Orthostatic Tachycardia Syndrome BACKGROUND Long COVID postural orthostatic tachycardia syndrome (LCPOTS) is characterized by persistent orthostatic tachycardia and multiple constitutional symptoms, many of...

Shared autonomous HERV loci transcription identifies a unique circulating CD14+-xCR1+ mononuclear cell phenotype in a patient group with post-acute sequelae of COVID-19 The human genome contains approximately 3,200 near full-length autonomous human endogenous retroviral (HERV) loci capable of...

Plasma Extracellular Vesicle Surface Marker Profiling Reveals Immune Cell–Associated Mitochondrial Membrane Potential Alterations in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome BACKGROUND Long COVID (LC) is characterized by symptoms persisting at least 3 months after...

An imaging flow cytometry method to study platelet-monocyte aggregates using Long COVID as a model Background Long COVID is characterised by persistent systemic inflammation and endothelial dysfunction, with increasing evidence implicating thromboinflammatory mechanisms. Platelet-monocyte...

Summary A previously healthy 39-year-old man developed highly symptomatic post-COVID-19 condition (also known as long COVID) marked by cognitive dysfunction, disabling fatigue, and autonomic symptoms unresponsive to multiple multidisciplinary interventions. Given the presence of markedly...

CD38 ligation plays a direct role in the induction of IL-1β, IL-6, and IL-10 secretion in resting human monocytes Abstract CD38 signaling, either induced by ligation with specific agonistic monoclonal antibody (mAb) or after interaction with CD31, its cognate counter-receptor, is involved in...

CD169+ and HLA-DR+ extracellular vesicles are highly represented in human plasma and dynamically expressed in SARS-CoV-2 infection and long COVID-associated sequelae INTRODUCTION Elevated inflammation and immune dysregulation are the main consequences of severe acute respiratory syndrome...

Full title: Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9–associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS The cellular mechanisms underlying Long COVID (LC) associated with myalgic...

https://www.nature.com/articles/s41590-025-02399-x Authors: Annukka A. R. Antar, Elizabeth C. Pasetes, Kay’La M. Z. Brennon & Andrea L. Cox Distinct monocyte gene expression programs were identified in people with long COVID after mild-to-moderate COVID-19 versus severe acute COVID-19...

Spaceflight alters molecular networks linked to diverse human diseases in a single cellular model The International Space Station provides an opportunity to study the impact of spaceflight on gene expression and possible links to human health. Our study investigates global changes in messenger...

Moved post --------------- There is a brief abstract in the supplement to the Journal of Immunology - Single cell epigenomic profiling identifies a distinct classical monocyte subset driving inflammation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME) Not sure if this needs a...

Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential BACKGROUND Postacute sequelae of SARS-CoV-2 infection, also known as long COVID (LC), is a complex and heterogenous condition affecting millions worldwide with a...

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00522-1 Highlights • Female long COVID (LC) patients show heightened immune activation and inflammation • Disrupted sex hormone levels differ between male and female LC patients • Neuroinflammatory gene signatures may explain...

Inflammatory predictors of Post-COVID fatigue A. Nuber-Champier, G. Breville, P. Voruz, I. Jacot de Alcântara, P.H. Lalive, G. Allali, L. Benzakour, K.-O. Lövblad, O. Braillard, M. Nehme, M. Coen, J. Serratrice, J.-L. Reny, J. Pugin, I. Guessous, B.N. Landis, A. Cionca, F. Assal, J.A. Péron...

Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome Anne E. Gardella, Daniel Eweis-LaBolle, Conor J. Loy, Emma D. Belcher, Joan S. Lenz, Carl J. Franconi, Sally Y. Scofield, Andrew Grimson, Maureen R. Hanson, Iwijn De...

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women Salker, Madhuri S. ; Abd Aziz, Nor Haslinda ; Prodan, Natalia Carman ; Yang, Zhiqi ; Lankapalli, Aditya Kumar ; Lazar, Katrin ; Shafiee, Mohamad Nasir ; Kocak, Ersoy ; Ganesan, Harivignesh...

Abstract: Background Sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B) is emerging as a potential biomarker and therapeutic target in myalgic encephalomyelitis (ME), a complex multisystem disorder characterized by immune dysfunction, metabolic disturbances, and persistent fatigue. This...