monocytes

IIMEC15 08 Professor Maureen Hanson 15th Invest in ME Research International ME Conference 2023 29 minutes Terrific presentation from Professor Maureen Hanson including some unpublished work I think we are getting close to some real answers - exhausted t-cells, abnormal classical monocytes...

Vagus nerve inflammation contributes to dysautonomia in COVID-19 Woo, Marcel S.; Shafiq, Mohsin; Fitzek, Antonia; Dottermusch, Matthias; Altmeppen, Hermann; Mohammadi, Behnam; Mayer, Christina; Bal, Lukas C.; Raich, Lukas; Matschke, Jakob; Krasemann, Susanne; Pfefferle, Susanne; Brehm, Thomas...

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by...

Trained immunity in human monocyte enhances myeloid-T-cell pathogenic crosstalk in Ankylosing Spondylitis Jinyi Zhao; Feng Liu; Claudia Worth; Davide Simone; Frank Penkava; Hui Shi; Jiaqi Li; Shristi Lama; Hai Fang; Jeong Seok Lee; Tae-Jong Kim; Lihua Duan; Paul Bowness; Liye Chen Recent...

Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues Brianna M Doratt; Suhas Sureshchandra; Heather True; Monica Rincon; Nicole E Marshall; Ilhem Messaoudi Few studies have addressed the impact of...

Elevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals Park, Juwon; Dean, Logan S.; Jiyarom, Boonyanudh; Gangcuangco, Louie Mar; Shah, Parthav; Awamura, Thomas; Ching, Lauren L.; Nerurkar, Vivek R.; Chow, Dominic C.; Igno, Fritzie; Shikuma, Cecilia M...

https://www.nature.com/articles/s41564-023-01349-3 The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. Previous studies show...

:emoji_warning: At this point it's still a preprint. Abstract: As most of you know, in the 80s researchers were excited about several (and separate) finds of retroviral activity in what we now call ME/CFS patients. The main researcher was Elaine DeFreitas, whose finds got dismissed by UK...

Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19 Sparks R, Lau WW, Liu C, Han KL, Vrindten KL, Sun G, Cox M, Andrews SF, Bansal N, Failla LE, Manischewitz J, Grubbs G, King LR, Koroleva G, Leimenstoll S, Snow L; OP11 Clinical Staff; Chen J, Tang J, Mukherjee A, Sellers...

Abstract Background COVID-19 is associated with a dysregulated immune response but it is unclear how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 patients during convalescence (long COVID). Methods We assessed phenotypical and functional changes of...

Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19 Hopkins FR, Govender M, Svanberg C, Nordgren J, Waller H, Nilsdotter-Augustinsson Å, Henningsson AJ, Hagbom M, Sjöwall J, Nyström S, Larsson M Introduction: After more than two...

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 Maher, Allison K; Burnham, Katie L; Jones, Emma M; Tan, Michelle MH; Saputil, Rocel C; Baillon, Laury; Selck, Claudia; Giang, Nicolas; Argüello, Rafael; Pillay, Clio; Thorley, Emma...

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five...

Preprint https://www.biorxiv.org/content/10.1101/2022.10.13.512091v1 SUMMARY ME/CFS is a serious and poorly understood disease. To understand immune dysregulation in ME/CFS, we used single-cell RNA-seq (scRNA-seq) to examine immune cells in cohorts of patients and controls. Post-exertional...

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post-acute sequelae of COVID-19 Christoph Schultheiss, Edith Willscher, Lisa Paschold, Cornelia Gottschick, Bianca Klee, Lidia Bosurgi, Jochen Dutzmann, Daniel...

Severe fatigue as symptom of long COVID is characterized by increased expression of inflammatory genes in monocytes, increased serum pro-inflammatory cytokines, and increased CD8+ T-lymphocytes. A putative dysregulation of the immune-brain axis, the coagulation process, and auto-inflammation to...

Preprint https://www.researchsquare.com/article/rs-1344323/v1 Post-acute sequelae of COVID (PASC), or long COVID, is a multisystem complication of SARS-CoV-2 infection that continues to debilitate millions worldwide thus highlighting the public health importance of identifying effective...

Pure speculation but maybe this line of research or the methods used in the paper to understand immune cell metabolic reprogramming via single-cell multiomics could eventually help explain whatever possible cellular metabolic changes that are triggered and persist in Long COVID and ME/CFS…...

https://www.biorxiv.org/content/10.1101/2021.06.25.449905v2 The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 infection (PASC) may affect up to 30% of all infected...

I'm asking because for me they seem to be consistently slightly elevated, in the 8.5-9.5 range. Not that I have a million test results but the few I have are consistent and this is the only value that is off. I have very very mild Hashimoto's thyroiditis and I asked the endocrinologist at the...