neuroinflammation

Immunopharmacological mechanisms underlying SARS-CoV-2 spike-induced persistent pain in mice SARS-CoV-2 infection is frequently associated with persistent pain, yet the underlying mechanisms remain poorly understood. Given that viral structural proteins can act as pathogen-associated molecular...

Integrated meta-analysis of human astrocytes transcriptomes reveals a candidate recurrent inflammatory signature in response to inflammatory and immune stimuli Abstract Astrocytes are key regulators of inflammatory and immune responses in the central nervous system, particularly under...

Full title: Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in a mouse model for post-streptococcal encephalitis Abstract Group A Streptococcus (GAS) infections cause neuropsychiatric complications in children, but the mechanisms linking peripheral...

Neuroinflammation, Pericyte Dysfunction, and Alzheimer’s Disease-Associated Gene Expression and Pathway Activation in the Brain of SARS-CoV-2-Infected Mice Abstract SARS-CoV-2 infection leads to extrapulmonary complications in multiple organs, including the brain, both in the short-term and...

Evaluation of neuronal and immunological biomarkers in post-COVID-19 condition Highlights Plasma biomarkers reveal persistent inflammation in post-COVID condition (PCC) volunteers. Volunteers with neurological symptoms PCC-NS showed high IgA levels. PCC-NS volunteers presented elevated...

Chronic stress primes TLR3-mediated systemic inflammation to produce persistent post-viral fatigue syndrome-like symptoms in mice Highlights • Chronic stress in combination with poly I:C produces persistent multi-domain PVFS-like symptoms in mice. • Minocycline attenuates fatigue...

Association between post-COVID-19 neuropsychiatric symptoms and persistent glial activation in the limbic system: a TSPO PET study Background A subset of individuals experience prolonged neurological and psychiatric symptoms following SARS-CoV-2 infection, a condition referred to as long...

Decreased functional connectivity in post-COVID syndrome patients with high neuroinflammatory activity INTRODUCTION Previous research suggests some post-COVID patients with neurocognitive complaints (NCC) show neuroinflammation. Like in inflammatory diseases, this may affect network...

Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice Cognitive impairment is a disabling feature of Long COVID, with data supporting neuroinflammation and maladaptive glial responses as primary...

Cognitive and Neuropsychiatric Sequelae After SARS-CoV-2 Infection: A Narrative Review and Exploratory Cross-Sectional Study of Neurofilament Light Chain and GFAP BACKGROUND Persistent cognitive and neuropsychiatric symptoms have been increasingly reported as part of the post-COVID-19...

ABSTRACT Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder with suspected neuroinflammatory pathophysiology. However, previous diffusion tensor imaging (DTI) studies have reported inconsistent white matter abnormalities in ME/CFS, and specific white...

Advancing understanding of long COVID pathophysiology through quantum walk-based network analysis MOTIVATION Long COVID is a multisystem condition characterized by persistent symptoms such as fatigue, cognitive impairment, and systemic inflammation following COVID-19 infection. However, its...

Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation–a controlled study An unedited version of the manuscript Background Long-COVID remains incompletely understood, particularly regarding the roles of peripheral...

Neuroinflammation: an unfortunate term to describe schizophrenia Abstract Schizophrenia, a chronic psychiatric disorder, has prompted extensive research into its immunological aspects. Studies in genetics, epidemiology, and treatment have revealed immune changes associated with schizophrenia...

Assessing cerebral capillary function and stalling using single capillary reporters in ultrasound localization microscopy While transcranial neuroimaging of individual capillary function holds transformative potential for diagnostics, it has proven difficult to achieve. Superresolution...

Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is...

Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques Although most SARS-CoV-2 infections result in mild or moderate symptoms not requiring hospitalization, many patients experience persistent symptoms after their initial recovery, a...

Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies Nociplastic pain has recently been introduced as a third entity for identifying patients suffering from chronic pain that arises from altered nociception...

Brain MRI findings in patients with post COVID-19 condition: frequency and longitudinal changes in a nationwide cohort study BACKGROUND Prolonged neurological symptoms following COVID-19 are common, yet few longitudinal studies describe brain MRI findings in this patient group. The use of...

Underlying cause of Gulf War illness confirmed Link to research: Decadelong low basal ganglia NAA/tCr from elevated tCr supports ATP depletion from mitochondrial dysfunction and neuroinflammation in Gulf War illness