neuroinflammation

The Human Microglia Atlas HuMicA Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions Ricardo Martins-Ferreira; Josep Calafell-Segura; Barbara Leal; Javier Rodriguez-Ubreva; Elisabetta Mereu; Paulo Pinho e Costa; Esteban Ballestar...

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions Fransen, Nina L; Hsiao, Cheng-Chih; van der Poel, Marlijn; Engelenburg, Hendrik J; Verdaasdonk, Kim; Vincenten, Maria C J; Remmerswaal, Ester B M; Kuhlmann, Tanja; Mason, Matthew R J; Hamann...

Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques Nieuwland, Juliana M.; Nutma, Erik; Philippens, Ingrid H. C. H. M.; Böszörményi, Kinga P.; Remarque, Edmond J.; Bakker, Jaco; Meijer, Lisette; Woerdman...

No evidence for the association between COVID-19 and neuroinflammation: A diffusion basis spectrum imaging study. Wei Zhang; Aaron J Gorelik; Qing Wang; Sara A Norton; Tamara Hershey; Janine D Bijsterbosch; Ryan Bogdan COVID continues to be a major international public health concern, the...

Hippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome Maria Díez-Cirarda; Miguel Yus-Fuertes; Rafael Sanchez-Sanchez; Javier J. Gonzalez-Rosa; Gabriel Gonzalez-Escamilla; Lidia Gil-Martínez; Cristina Delgado-Alonso...

Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis Eva Heckova; Assunta Dal-Bianco; Bernhard Strasser; Gilbert J. Hangel; Alexandra Lipka; Stanislav Motyka; Lukas Hingerl; Paulus S. Rommer; Thomas Berger; Petra...

Perivascular spaces and their role in neuroinflammation Benjamin V. Ineichen; Serhat V. Okar; Steven T. Proulx; Britta Engelhardt; Hans Lassmann; Daniel S. Reich It is uncontested that perivascular spaces play critical roles in maintaining homeostasis and priming neuroinflammation. However...

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by...

Key Points Question Is translocator protein distribution volume (TSPO VT), an index of gliosis (an inflammatory change), measured by positron emission tomography, elevated in the brain after acute COVID-19 infection with sequelae of depressive and cognitive symptoms? Findings In this...

Free-water-corrected diffusion and adrenergic/muscarinic antibodies in myalgic encephalomyelitis/chronic fatigue syndrome Yukio Kimura; Wakiro Sato; Norihide Maikusa; Miho Ota; Yoko Shigemoto; Emiko Chiba; Elly Arizono; Hiroyuki Maki; Isu Shin; Keiko Amano; Hiroshi Matsuda; Takashi Yamamura...

Abnormal brain diffusivity in participants with persistent neuropsychiatric symptoms after COVID-19 Huajun Liang; Thomas Ernst; Kenichi Oishi; Meghann C. Ryan; Edward Herskovits; Eric Cunningham; Eleanor Wilson; Shyamasundaran Kottilil; Linda Chang Objectives We aimed to compare brain white...

The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways O'Connor, Jennifer L.; Nissen, Jillian C. Microglia are the primary immunocompetent cells of the central nervous system (CNS). Their ability to survey, assess and respond to perturbations in their local...

Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis Bashir, Shah Tauseef; Redden, Catherine R.; Raj, Kishori; Arcanjo, Rachel B.; Stasiak, Sandra; Li, Quanxi; Steelman, Andrew J.; Nowak, Romana A. Chronic pelvic pain (CPP) is a common symptom of...

Abstract Multiple sclerosis (MS) is a T cell-driven autoimmune disease that attacks the myelin of the central nervous system (CNS) and currently has no cure. MS etiology is linked to both the gut flora and external environmental factors but this connection is not well understood. One immune...

Sex differences in the blood-brain barrier: Implications for mental health Dion-Albert L, Bandeira Binder L, Daigle B, Hong-Minh A, Lebel M, Menard C Prevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ) are increasing at...

Semi-automated Segmentation and Quantification of Perivascular Spaces at 7 Tesla in COVID-19 Langan MT, Smith DA, Verma G, Khegai O, Saju S, Rashid S, Ranti D, Markowitz M, Belani P, Jette N, Mathew B, Goldstein J, Kirsch CFE, Morris LS, Becker JH, Delman BN, Balchandani P While COVID-19 is...

Preprint See post 5 for published version Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer’s disease individuals Elizabeth Griggs, Kyle Trageser, Sean Naughton, Eun-Jeong Yang, Brian Mathew, Grace Van Hyfte, Linh Hellmers, Nathalie Jette, Molly Estill, Li Shen, Tracy...

Published version linked in a later post ***** Preprint Choroid Plexus calcification correlates with cortical microglial activation in humans: a multimodal PET, CT, MRI study Tracy Butler, X. Hugh Wang, Gloria C. Chiang, Yi Li, Liangdong Zhou, Ke Xi, NimmiWickramasuriya, Emily Tanzi, Edward...

Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study Etter MM, Martins TA, Kulsvehagen L, Pössnecker E, Duchemin W, Hogan S, Sanabria-Diaz G, Müller J, Chiappini A, Rychen J, Eberhard N, Guzman R, Mariani L...

[This seems to be only very tenuously about ME/CFS] Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown etiology and without effective treatment options. The onset of ME/CFS is often associated with neuroinflammation following bacterial or...