neutrophils

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition Abstract Background Post COVID-19 condition (PCC) is characterized by persistent, heterogeneous symptoms, most prominently affecting the cardiopulmonary system, yet its underlying biological...

A brief report: absence of elevated circulating NETosis markers in long-term long COVID Background Neutrophil extracellular trap (NET) formation (NETosis) has been proposed as a contributor to the pathophysiology of Long COVID (LC). However, it remains unclear whether markers of systemic...

Intestinal flagellin drives multisystem inflammation through TLR5-IL-15-ARA axis BACKGROUND Systemic inflammatory diseases including rheumatoid arthritis (RA), ankylosing spondylitis (AS), IBD and long covid share convergent multi-organ phenotypes. Long covid provides a tractable model for...

Dynamic Coagulation Function Changes in COVID-19 Survivors With Coronary Artery Disease Coronary artery disease (CAD) and Coronavirus disease 2019 (COVID-19) are both associated with a hypercoagulable state, yet the long-term interaction between these prothrombotic conditions remains poorly...

Immunothrombosis in hospitalized COVID-19 patients identified by multiomics profiling and linked to postacute complications Post-acute sequelae of COVID-19 (PASC) disproportionately affect hospitalized patients and require improved molecular characterization to inform patient management...

De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection Abstract Background Glucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that...

Immune-metabolic trajectories delineate subgroups in paediatric long COVID Most children and adolescents recover rapidly from SARS-CoV-2 infection, yet a subset develops paediatric long COVID (LC). How immune ontogeny shapes LC biology and heterogeneity remains unclear. We deeply phenotype a...

Endovascular profiles linked to neutrophil activation in children and young adults with long COVID Endovascular symptoms are among the most debilitating long COVID symptoms; however, underlying mechanisms are unclear. Children and young adults with long COVID, an understudied population, offer...

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients Abstract Chronic persistence of systemic symptoms after recovery from active CoVID-19 has become a significant disease burden, named post-CoVID syndrome...

Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19 Immunometabolism and neutrophil extracellular traps (NETs) play pivotal roles in the pathogenesis of coronavirus disease 2019 (COVID-19) and its postacute sequelae. However, the...

Immune transcriptomic changes in Australian Gulf War veterans Eaton-Fitch, Natalie; Sasso, Etianne Martini; Marshall-Gradisnik, Sonya [Line breaks added] Background Gulf War Illness (GWI) is a chronic multisystemic illness found in one-third of Gulf War Veterans. The aetiology of GWI is...

Sars-Cov-2 spike protein and plasma from COVID-19 patients induce extracellular traps by myeloid-derived suppressor cells INTRODUCTION Polymorphonuclear-myeloid-derived suppressor cells (PMN-MDSC) are elevated in COVID-19 patients, playing a crucial role in suppressing the SARS-CoV-2 specific...

The potential bidirectional relationship between long COVID and menstruation Women have reported menstrual changes following SARS-CoV-2 infection and variation in long COVID symptoms across the menstrual cycle. We examined (i) whether COVID is linked to abnormal uterine bleeding (AUB), (ii) if...

Interferon-Linked Lipid and Bile Acid Imbalance Uncovered in Ankylosing Spondylitis in a Sibling-Controlled Multi-Omics Study Ankylosing spondylitis (AS) displays wide inter-patient variability that is not accounted for by HLA-B27 alone, suggesting that additional immune and metabolic...

DecodeMe Candidate Gene CHROMOSOME 13 Chr13 contained no Tier 1 genes and one Tier 2 gene. ******************** OLFM4 (Tier 2) • Protein: Olfactomedin-4. UniProt. GeneCards. • Molecular function: OLFM4 facilitates cell adhesion, most probably through interaction with cell surface lectins...

A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response...

Evidence for a role of skull bone marrow in human chronic pain as revealed by TSPO PET imaging The skull bone marrow is emerging as a critical hub for neuroimmune signaling in various disorders, with the potential to reshape how we understand brain-immune interactions. However, its role in...

Increased neutrophil apoptosis in chronic fatigue syndrome G Kennedy; V Spence; C Underwood; J J F Belch BACKGROUND / AIMS Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs...

Integrative Bioinformatics Analysis Identifies Peripheral Blood Hub Genes and Establishes a Five-Gene Diagnostic Model for Long COVID Yang Liu, Yuwei Shen, Peilian Cao, Yuqiang Qian, Yutong Chen, Daxing Jiang, Jianan Li [Line breaks added] Background Long COVID (LC) is a multisystem condition...

SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19 Aiswarya Mukundan Nair; Helen Piontkivska Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections remain a public health concern worldwide. Viral antigen...