Blood Immuno-metabolic Biomarker Signatures of Depression and Affective Symptoms in Young Adults
Nicholas Donnelly, Ruby Tsang, Èimear M Foley, Holly Fraser, Aimee Hanson, Golam M Khandaker
Background
Depression is associated with alterations in immuno-metabolic biomarkers, but it remains...
The physio-affective symptoms of Long COVID are strongly predicted by the severity of the acute infectious phase, and lowered antioxidant, nitric oxide, and alanine transaminase levels
Michael Maes, Chavit Tunvirachaisakul, Laura de Oliveira Semão, Ana Paula Michelin, Andressa Matsumoto...
January 22, 2025
The University Hospital Regensburg (UKR) is initiating the "Miracle" project together with the University Hospital Gießen and Marburg (UKGM) to research the mysterious disease Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disease is a massive burden for those...
Exercise intensity and training alter the innate immune cell type and chromosomal origins of circulating cell-free DNA in humans
Rodrigues, Kameron B.; Weng, Ziming; Graham, Zachary A.; Lavin, Kaleen; McAdam, Jeremy; Tuggle, S. Craig; Peoples, Brandon; Seay, Regina; Yang, Sufen; Bamman, Marcas...
Platelets as key cells in endometriosis patients: Insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis
Barbara Bortot; Roberta Di Florio; Simona Merighi; Ben Peacock; Rebecca Lees; Francesco Valle; Marco Brucale; Alessandro Mangogna; Giovanni Di...
Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients
Shahbaz; Rezaeifar; Syed; Redmond; Terveart; Osman; Elahi
A substantial portion of patients infected with SARS-CoV-2 experience prolonged complications...
Background
Many children suffer from lingering symptoms after COVID-19, known as long COVID syndrome (LCS), otherwise called Post COVID-19 Condition (PCC). Despite extensive research, the prevalence of symptoms, its impact on quality of life, and underlying mechanisms still need to be fully...
Neutrophil Elastase, Neuron-Specific Enolase, and S100B Protein as Potential Markers of Long-Term Complications Caused by COVID-19 in Patients with Type 2 Diabetes Mellitus T2DM and Advanced Stage of Diabetic Nephropathy NfT2DM—Observational Studies
Rabczyński, Maciej; Chwałek, Sandra...
Association of vascular netosis with COVID-19 severity in asymptomatic and symptomatic patients
Suman Kapoor; Lucia Mihalovičová; Ekaterina Pisareva; Brice Pastor; Alexia Mirandola; Benoit Roch; Joe Bryant; Anna Philip Princy; Salem Chouaib; Alain Roger Thierry
We examined from a large...
Inflammation-, immunothrombosis,- and autoimmune-feedback loops may lead to persistent neutrophil self-stimulation in long COVID
Alain R. Thierry; Dominique Salmon
Understanding the pathophysiology of long COVID is one of the most intriguing challenges confronting contemporary medicine. Despite...
Abstract
Background
Omicron variant impacts populations with its rapid contagiousness, and part of patients suffered from persistent symptoms termed as long COVID. The molecular and immune mechanisms of this currently dominant global variant leading to long COVID remain unclear, due to long...
The choroid plexus synergizes with immune cells during neuroinflammation
Huixin Xu; Peter Lotfy; Sivan Gelb; Aja Pragana; Christine Hehnly; Lillian I.J. Byer; Frederick B. Shipley; Miriam E. Zawadzki; Jin Cui; Liwen Deng; Milo Taylor; Mya Webb; Hart G.W. Lidov; Mark L. Andermann; Isaac M. Chiu...
Identification of a forkhead box protein transcriptional network induced in human neutrophils in response to inflammatory stimuli
Ismailova, Aiten; Salehi-Tabar, Reyhaneh; Dimitrov, Vassil; Memari, Babak; Barbier, Camille; White, John H.
Introduction: Neutrophils represent the largest...
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time
Giuseppe Gianini Figueirêdo Leite; Milena Karina Colo Brunialti; Paula M. Peçanha-Pietrobom; Paulo R. Abrão Ferreira; Jaquelina Sonoe Ota-Arakaki; Edecio...
Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants
Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...
Now published - details here
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Preprint
Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection
Aleksandra K Drelich; Kempaiah Rayavara; Jason Hsu; Panatda Saenkham-Huntsinger...
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