Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers
Miguel Galan, Lorena Vigon, Daniel Fuertes, Marıa Aranzazu Murciano-Anton, Guiomar Casado-Fernandez, Susana Domınguez-Mateos, Elena Mateos, Fernando...
The pathophysiology of fibromyalgia syndrome (FMS) remains elusive, leading to a lack of objective diagnostic criteria and targeted treatment.
We globally evaluated immune system changes in FMS by conducting multiparametric flow cytometry analyses of peripheral blood mononuclear cells and...
Characterization of IL-2 Stimulation and TRPM7 Pharmacomodulation in NK Cell Cytotoxicity and Channel Co-Localization with PIP2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystemic disorder...
Pure speculation but maybe this line of research or the methods used in the paper to understand immune cell metabolic reprogramming via single-cell multiomics could eventually help explain whatever possible cellular metabolic changes that are triggered and persist in Long COVID and ME/CFS…...
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Abstract
Documenting the importance of NK cell function as a biomarker for diseases and physiologic conditions including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), will require assays amenable to clinical implementation and standardization. Research studies typically perform...
Full title:
Impact of Long-Term Cryopreservation on Blood Immune Cell Markers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Biomarker Discovery
https://www.frontiersin.org/articles/10.3389/fimmu.2020.582330/full
Open access at https://www.nature.com/articles/s41467-018-04685-9
Article about the study
https://ki.se/en/news/immune-system-does-not-recover-despite-cured-hepatitis-c-infection
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