pain

Highlights • Transplanting gut microbiota from women with fibromyalgia into mice induces pain • It also induces immune activation, metabolomic changes, and reduced skin innervation • Gut microbiota promotes pain through several mechanisms Summary Fibromyalgia is a prevalent syndrome...

Scientists pinpoint cause of migraines - paves way for new treatment

PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain Sbei, Sami; Moncrief, Taylor; Limjunyawong, Nathachit; Zeng, Yaping; Green, Dustin P. Migraine ranks among the most prevalent disorders worldwide, leading to disability and decreased quality of life in patients...

Abstract Background: This study aims to explore the perceptions and clinical approaches of pain management specialists toward myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a condition characterized by persistent fatigue, widespread pain, unrefreshing sleep, and autonomic...

Commonly used interventional procedures for non-cancer chronic spine pain: a clinical practice guideline Jason W Busse; Stéphane Genevay; Arnav Agarwal; Christopher J Standaert; Kevin Carneiro; Jason Friedrich; Manuela Ferreira; Hilde Verbeke; Jens Ivar Brox; Hong Xiao; Jasmeer Singh Virdee...

Abstract: Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ...

The psychological and physiological effects of a virtual reality-based treatment program in female patients with fibromyalgia syndrome: A randomized controlled trial. Sari et al, 2025 Abstract The study aims to evaluate the effects of virtual reality (VR) programs on disease activity, central...

Abstract Objectives To summarize and evaluate Cochrane reviews of pharmacological therapies for adults with fibromyalgia syndrome (FMS) pain. Methods Systematic search of Cochrane Database of Systematic Reviews to May 2024. Generic quality assessment used AMSTAR-2 criteria, validity checks of...

This post has been copied and some following posts moved I don’t know how common it is, but chostochondritis is regularly reported in social media. With me it varies with my ME, and when I was at my worst the pain was one of my most disabling symptoms. Currently it is only there when I am in...

Hippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study Kiran Thapaliya; Sonya Marshall-Gradisnik; Natalie Eaton-Fitch; Markus Barth; Maira Inderyas; Leighton Barnden Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue...

Pain Coping Skills Training for Patients Receiving Hemodialysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2828284 Abstract Importance: Chronic pain is common among individuals with dialysis-dependent kidney failure. Objective: To evaluate the effectiveness of pain...

PGE2 and HCN2 ion channels are critical mediators of pain initiated by angiotensin II Pinto; Vilar; McNaughton Angiotensin II is well known to have an important influence on blood pressure, mediated via the angiotensin II type 1 receptor (AT1R), and more recent studies have shown that...

Preprint Abstract Background: Sex differences have been widely demonstrated in both acute and chronic pain. Sex differences may have wider impact on research design and analysis than already established. This study addresses an important methodological aspect with regards to how sex differences...

Association Between Chronic Pain and Fatigue Severity with Weather and Air Pollution Among Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Chloe Lisette Jones, Olivia Haskin, Jarred Wayne Younger Abstract Weather and air quality conditions have been anecdotally...

Spanish authors…. I did not read beyond the abstract. it seems rather stunning to me that this is considered science… https://pubmed.ncbi.nlm.nih.gov/39557041/ I found a pre-print here...

Following up on a mini discussion here: I'll make a poll on this thread to see if there's some trend toward one painkiller being more effective for people with ME/CFS. I've always thought it was interesting that aspirin and Tylenol seem to do nothing for me, at least at recommended doses...

STING recognition of viral dsDNA by nociceptors mediates pain in mice https://www.sciencedirect.com/science/article/pii/S0889159124004823 Highlights Nociceptors can directly sense viral nucleic acids, such as dsDNA derived from herpes and vaccinia viruses. Cytosolic dsDNA causes nocifensive...

Background Chronic overlapping pain conditions (COPCs), pain-related conditions that frequently occur together, may occur in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and could impact illness severity. This study aimed to identify comorbid COPCs in patients with...

Have been looking into the relationship between hypermobility on the one hand and pain, disability and health on the other. In other words: do people with hypermobility have more pain and worse health dan people without hypermobility? It seems that there have been quite a few population-based...

Now published - link here ******************** The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people...