pem

  1. Trish

    A brief, comprehensive measure of post-exertional malaise, 2025, Jason and Chee

    A brief, comprehensive measure of post-exertional malaise, Jason and Chee https://www.explorationpub.com/Journals/ent/Article/1004116 Abstract Aim: Post-exertional malaise (PEM) has been a challenging construct to measure, particularly with self-report instruments, which have the benefits of...
  2. John Mac

    American College of Sports Medicine’s Guidelines for Exercise Testing

    New CPET Guidelines: What They Mean for People with ME/CFS The American College of Sports Medicine’s Guidelines for Exercise Testing and Prescription, for the first time, includes a section on ME/CFS. ACSM is a leading authority on exercise science, and these guidelines serve as a foundational...
  3. SNT Gatchaman

    Heightened innate immunity may trigger chronic inflammation, fatigue and [PEM]…, 2025, Che, Hornig, Bateman, Klimas, Komaroff, Lipkin+

    Link to published paper here Preprint: Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive...
  4. ahimsa

    DePaul University, Center for Community Research: Symptom Questionnaires

    I thought it would be helpful to post a link to the DePaul University web page with their symptom questionnaires: https://csh.depaul.edu/about/centers-and-institutes/ccr/myalgic-encephalomyelitis-cfs/Pages/measures.aspx
  5. Trish

    Open DSQ PEM survey - DePaul University, open October 2025

    Copy of Facebook post by Leonard Jason: From the DePaul Group: Are you 18 or older? Do you experience Post-Exertional Malaise? Or are you a member of the general population interested in contributing to research? We are conducting a brief online survey as part of a research study focused on...
  6. M

    Do sleep medication or sleep aids support PEM recovery?

    I am currently going through a pretty bad PEM episode (it's actually the first time I realise I have PEM; I used to call it 'a setback'). One of the symptoms is insomnia/sleep disturbances (trouble falling asleep and staying asleep). It makes sense to me that better quality sleep would support...
  7. John Mac

    Trial Report Precision Medicine Study of Post-Exertional Malaise Epigenetic Changes in ME/CFS Patients During Exercise, 2025, Tate et al

    Abstract Post-exertional malaise (PEM) is a defining symptom of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), yet its molecular underpinnings remain elusive. This study investigated the temporal–longitudinal DNA methylation changes associated with PEM using a structured two-day...
  8. Sasha

    Do you have fever as a part of PEM?

    I've never heard of this, but a quick forum search on 'fever PEM' brought up this from last Thursday (my bolding): That's a really big surprise to me. Worth a thread of its own or a poll?
  9. Hoopoe

    A hypothesis involving maintenance and restorative processes in ME/CFS

    PEM is generally the main cause of disability in ME/CFS and it is typically delayed with respect to the activity that triggered it. It seems possible that PEM is closely related to maintenance and restorative processes that occur in the body. More activity during the day would lead to more...
  10. forestglip

    Exercise-Induced Symptom Exacerbation and Adverse Events in Moderate-to-Severe Traumatic Brain Injury, 2025, Gallow et al

    Exercise-Induced Symptom Exacerbation and Adverse Events in Moderate-to-Severe Traumatic Brain Injury Gallow, Sara BPhysio; McGinley, Jennifer PhD; Olver, John MD, FAFRM; McKenzie, Dean PhD; Williams, Gavin PhD Objective To determine the incidence of exercise-induced symptom exacerbation and...
  11. John Mac

    Trial Report Fatigue, Interoplastic and Nociplastic Distress in ME/CFS, Gulf War Illness and Chronic Idiopathic Fatigue, 2025, Baraniuk et al

    Full title: Fatigue, Interoplastic and Nociplastic Distress in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome, Gulf War Illness and Chronic Idiopathic Fatigue https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1530652/abstract Myalgic Encephalomyelitis /...
  12. forestglip

    Postorgasmic Illness Syndrome: Insights from Recent Literature on a Rare but Fascinating Disorder, 2025, Wdowiak et al

    Postorgasmic Illness Syndrome: Insights from Recent Literature on a Rare but Fascinating Disorder Krystian Wdowiak, Agnieszka Maciocha & Julia Wąż [Line breaks added] Abstract Post-orgasmic illness syndrome (POIS) is a rare condition characterised by flu-like and allergic symptoms that...
  13. forestglip

    368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in [ME/CFS] and Post-acute Sequelae of SARS-CoV-2 Infection, 2025, Berardi et al

    368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection Giovanni Berardi, Adam Janowski, Samuel McNally, Gregorius Bernhard, Alpana Garg, Kathleen Sluka Abstract Individuals with...
  14. forestglip

    Thesis Cerebral hemodynamics to acute exercise in Veterans with Gulf War Illness, 2025, Branchaw

    Cerebral hemodynamics to acute exercise in Veterans with Gulf War Illness Grace E. Branchaw Committee Members: Dr. Dane Cook, Chair Dr. Jill Barnes Dr. Jee-Seon Kim [Line breaks added] Introduction Gulf War Illness (GWI) is a chronic multisymptom illness (CMI) affecting approximately one...
  15. forestglip

    Physical activity and sedentariness levels in patients with post-exertional malaise resulting from post-COVID-19 syndrome, 2025, Elkebir et al

    Physical activity and sedentariness levels in patients with post-exertional malaise resulting from post-COVID-19 syndrome Kamel-Eddine Elkebir, Jo-Anne Gilbert, Thiffya Arabi Kugathasan, Camille Cazeneuve, Florian Chouchou, Marie-Eve Mathieu Background Post-exertional malaise (PEM) is a...
  16. hotblack

    Physical Therapy Management of Postural Orthostatic Tachycardia Syndrome Using a Pacing-Forward Clinical Approach: A Case Report, 2025, Powers et al

    Physical Therapy Management of Postural Orthostatic Tachycardia Syndrome Using a Pacing-Forward Clinical Approach: A Case Report Powers CD, Miranda NA, Davenport TE Abstract Objective: Postural Orthostatic Tachycardia Syndrome (POTS) is a form of autonomic dysfunction that affects hemodynamic...
  17. Hutan

    Post-Exertional Malaise in Long COVID: Subjective Reporting Versus Objective Assessment, 2025, Stussman, Nath, Walitt et al

    https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1534352/abstract Background: Post-exertional malaise (PEM) is a central feature of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and has emerged as a prominent feature of Long COVID. The optimal clinical...
  18. forestglip

    Preprint Wearable heart rate variability monitoring identifies autonomic dysfunction and thresholds for post-exertional malaise in Long COVID, 2025, Ruijgt+

    Wearable heart rate variability monitoring identifies autonomic dysfunction and thresholds for post-exertional malaise in Long COVID Twan Ruijgt, Anouk Slaghekke, Anneke Ellens, Kasper Janssen, Rob CI Wust Objectives Patients with Long COVID experience disabling fatigue, autonomic dysfunction...
  19. Trish

    PEM: A thread for sharing your experience of post-exertional malaise

    Do you get delayed PEM that makes your ME/CFS more severe for a day or more, up to and including permanently? I have started this thread to focus entirely on each poster describing your own experience of PEM. My aim is that we avoid theorising about the underlying biology - keep the focus on...
  20. forestglip

    Review Prevalence and Impact of [PEM] on Recovery in Adults with Post COVID-19 Condition. A Systematic Review with Meta-Analysis, 2025, Pouliopoulou et al

    Prevalence and Impact of Post-Exertional Malaise on Recovery in Adults with Post COVID-19 Condition. A Systematic Review with Meta-Analysis Dimitra V Pouliopoulou, Myranda Hawthorne, Joy C MacDermid, Nicole Billias, Erin Miller, Kieran Quinn, Simon Décary, Fahad A. Razak, Angela Cheung, Panagis...
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