pem

Physical Therapy Management of Postural Orthostatic Tachycardia Syndrome Using a Pacing-Forward Clinical Approach: A Case Report Powers CD, Miranda NA, Davenport TE Abstract Objective: Postural Orthostatic Tachycardia Syndrome (POTS) is a form of autonomic dysfunction that affects hemodynamic...

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1534352/abstract Background: Post-exertional malaise (PEM) is a central feature of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and has emerged as a prominent feature of Long COVID. The optimal clinical...

Wearable heart rate variability monitoring identifies autonomic dysfunction and thresholds for post-exertional malaise in Long COVID Twan Ruijgt, Anouk Slaghekke, Anneke Ellens, Kasper Janssen, Rob CI Wust Objectives Patients with Long COVID experience disabling fatigue, autonomic dysfunction...

Do you get delayed PEM that makes your ME/CFS more severe for a day or more, up to and including permanently? I have started this thread to focus entirely on each poster describing your own experience of PEM. My aim is that we avoid theorising about the underlying biology - keep the focus on...

Prevalence and Impact of Post-Exertional Malaise on Recovery in Adults with Post COVID-19 Condition. A Systematic Review with Meta-Analysis Dimitra V Pouliopoulou, Myranda Hawthorne, Joy C MacDermid, Nicole Billias, Erin Miller, Kieran Quinn, Simon Décary, Fahad A. Razak, Angela Cheung, Panagis...

https://www.lidsen.com/journals/neurobiology/neurobiology-09-01-267 Abstract Following mental or physical exertion, patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience Post-Exertional Malaise (PEM). Although self-report questions represent less expensive and...

Exertional Exhaustion Post-Exertional Malaise, PEM Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics and Serine Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Baraniuk, James N. Post-exertional malaise (PEM) is a defining condition of myalgic...

In the News From Germany thread, I posted about how I emailed a researcher about an upcoming study on sleep in ME/CFS. Snippet from my email: Snippet from Claudia Schilling's response: Does any metric exist for assessing whether one is in a crash at the moment, and/or how bad the crash is...

I read in a thread that some people find 30 second burst of high energy exercise helpful. I hadn't heard of that idea before and decided, why not give it a try to see if I am one of those people. I'm not. Anyway, didn't give me too bad of PEM. Most of it reared yesterday, today it's mild...

Abstract: Background and Purpose: As a result of COVID-19 infection, millions of individuals are now affected by Long COVID, and this number continues to increase. These individuals experience a multitude of symptoms and limitations that make accessing conventional rehabilitative care...

(masters thesis) Background: Post-COVID (PC) is characterized by prolonged symptoms following a COVID-19 infection, with Post-Exertional Malaise (PEM) being a feature with a large negative impact on quality of life. Mitochondrial dysfunction has previously been related to PEM-related symtpoms...

The most popular questionnaire for PEM is the De-Paul Symptom Questionnaire, which, to be frank, is not the best, as it mostly focuses on fatigue after exertion and seems to flag an unlikely proportion of people with other illnesses having PEM. It seems there isn’t much competition. The FUNCAP...

Quote: Identifying the phenomenon of post-exertional malaise (PEM) in patients with fatiguing conditions is critical because it necessitates a far more cautious approach to exercise, experts said. PEM is a defining feature of the condition myalgic encephalomyelitis/chronic fatigue syndrome...

Effects of a symptom-titrated exercise program on fatigue and quality of life in people with post-COVID condition – a randomized controlled trial Barz, Andreas; Berger, Joshua; Speicher, Marco; Morsch, Arne; Wanjek, Markus; Rissland, Jürgen; Jäger, Johannes Fatigue is the most prevalent symptom...

It seems cytotoxicity (the ability of a stressor to damage cells) can be a phenomenon that is delayed in comparison to the original stimulus. Ie. it seems depending on the immune or chemical leading to cytotoxicity it can occur instantaneously to a week after. [1] It seems also a well regarded...

Virtual rehabilitation for individuals with Long COVID: a randomized controlled trial Tania Janaudis-Ferreira; Marla K. Beauchamp; Amanda Rizk; Catherine M. Tansey; Maria Sedeno; Laura Barreto; Jean Bourbeau; Bryan A. Ross; Andrea Benedetti; Pei Zhi Li; Kriti Agarwal; Rebecca Zucco; Julie Lopez...

I thought It would be interesting to have a place to collect descriptions or accounts of living with other illnesses that include phenomena seemingly nearly identical to what we call PEM. For Mitochondrial disease, check out the thread: What differentiates ME/CFS from known primary...

Exercise leads to the release of a wide variety of substances, in the category of exerkines. https://www.nature.com/articles/s41574-022-00641-2 What if one or several of these exerkines were blunted in ME/CFS or, for some obscure reason, had a damaging effect instead of a health-promoting...

Guardian angels off duty? ME/CFS is Sustained by an Impaired Stress Response in the Central Nervous System Herbert Renz-Polster Abstract ME/CFS researchers agree that ME/CFS is a multisystem disease with a multitude of pathobiological features including endothelial dysfunction, immune...

I thought it might be worthwhile to have a discussion comparing and contrasting the symptoms of an acute infection (a week or two of flu, cold, staph, etc.) and ME/CFS. Viral persistence is often mentioned in discussions of mechanism theories. I personally think there's a good chance ME/CFS is...