pem

Prevalence and risk factors of adverse work outcomes among manufacturing workers with Long COVID in Malaysia – A nationwide study Abstract Introduction The increasing prevalence and multiorgan involvement of Long COVID among the general population has raised concerns about the possible...

Exercise Lactate in Post-COVID-19 Condition: Pathophysiological Signal, Phenotyping Tool, or Candidate Biomarker? A Narrative Review with a Hypothesis-Generating Clinical Observation Sakellaropoulos, Stefanos G.; Spedicato, Vanessa; Pfister, Otmar Abstract Post-COVID-19 condition (PCC)...

Registered interventional trials fail to cover patient-prioritised treatments in Post-COVID condition (PCC) Purpose Despite the substantial health and socioeconomic burden of Post-COVID condition (PCC), no disease-modifying therapy has been established, largely because of clinical...

Orthostatic Dysfunction and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Close Reciprocal Relationship Beyond Cardiac Preload Failure and Hypoperfusion Klaus J. Wirth Abstract Orthostatic dysfunction, including postural orthostatic tachycardia syndrome (POTS) is highly prevalent in...

A cardiometabolic perspective on post-exertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID Westermeier, Francisco; Pretorius, Etheresia; Untersmayr, Eva; Bertinat, Romina; Sepúlveda, Nuno; Fisman, Enrique Abstract Post-exertional malaise (PEM), the...

I had an email survey from OMF today specifically focused on PEM in preparation for upcoming research. From the email today:

Utilizing Wearable Technology to Characterize and Predict Post-Exertional Malaise Crashes across Post-COVID Syndrome and Chronic Inflammatory Conditions: Study Protocol of the prospective observational study ‘U-WaTCH’ Abstract Background: Fatigue and post-exertional malaise (PEM) are...

Agreement and reliability between the two-day 6-minute incremental step test and two-day cardiopulmonary exercise test in post COVID-19 condition for assessing post-exertional malaise: The REVEAL-study Abstract Background Post-Exertional Malaise (PEM) is a core symptom of post COVID-19...

Symptomatic hypermobility as a risk factor for Long COVID with high post-exertional symptom exacerbation: further analysis of data from a retrospective online survey of adults in the United States and United Kingdom Background In a retrospective online survey, we assessed the extent to which...

Development and initial content validation of the Vienna Post-Exertional Malaise Questionnaire: an iterative mixed-methods study Abstract Objectives Post-exertional malaise (PEM) is increasingly understood not as a singular symptom but as a multidimensional exertion-response pattern involving...

Safety of Cardiopulmonary Exercise Testing in Patients with Severe Post- COVID-19 Condition: A Matched Case- Control Study Abstract Patients severely affected by post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) exhibit reduced physical capacity...

Full title: Irisin Signaling Resistance in Myalgic Encephalomyelitis: A Proposed Mechanistic Framework for Post-Exertional Malaise Involving the TSP-1–HSP90α–αvβ5 Axis Abstract Myalgic Encephalomyelitis (ME) is a chronic, multisystem disease characterized by systemic metabolic dysfunction and...

Impact of post-exertional malaise frequency and fatigue in Long COVID patients on health-related quality of life PURPOSE The aim of this study was to investigate the impact of post-exertional malaise (PEM) frequency and PEM severity on health-related quality of life (HRQoL) among individuals...

Exercise advice for long covid may be doing more harm than good Exercise has been touted as a tool for managing and treating long covid, but much of the evidence has neglected one of its most debilitating symptoms: post-exertional malaise [url...

Pathophysiological mechanisms of post-exertional malaise: an integrative analysis based on the metabolism-immune-neuro interaction model Abstract Post-exertional malaise (PEM) is a common core symptom in various chronic debilitating conditions, such as Post COVID-19 Condition (PCC, also known...

I am curious how many people have experienced the phenomenon of being asymptomatic at baseline but still experiencing episodic PEM -- and when I say asymptomatic at baseline, that would include ability to do activities of daily living without rapidly fatiguing/bringing on symptoms - if you only...

Abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic illness with post-exertional malaise (PEM) as a key symptom. This study categorized participants with ME/CFS who met PEM criteria into four groups based on severity of physical and mental PEM: severe physical PEM...

Moved post --------------- There is a brief abstract in the supplement to the Journal of Immunology - Single cell epigenomic profiling identifies a distinct classical monocyte subset driving inflammation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME) Not sure if this needs a...

https://xcancel.com/robwust/status/1991503273484841039?s=12 Rob Wüst @RobWust ME/CFS & Long COVID patients: we need your help! We’re validating a new tool to measure post-exertional malaise (PEM). Current questionnaires don’t capture its severity or impact. Your input changes that! English...

Highlights • Plasma profiling of 7,288 proteins during post-exertional malaise in ME/CFS. • ME/CFS participants show sustained immune, metabolic, and neuromuscular dysregulation during post-exercise recovery. • Exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial...