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  1. cassava7
    Thread

    (…) overestimation of effects in randomized trials that fail to optimize randomization and blind patients and outcome assessors, Wang, Guyatt+, 2023

    Compelling evidence from meta-epidemiological studies demonstrates overestimation of effects in randomized trials that fail to optimize...
    Thread by: cassava7, Nov 9, 2023, 7 replies, in forum: Research methodology news and research
  2. SNT Gatchaman
    Thread

    Many High-Quality Randomized Controlled Trials in Sports Physical Therapy Are Making False-Positive Claims of Treatment Effect, 2020, Bleakley et al.

    Many High-Quality Randomized Controlled Trials in Sports Physical Therapy Are Making False-Positive Claims of Treatment Effect: A Systematic...
    Thread by: SNT Gatchaman, Sep 30, 2023, 0 replies, in forum: Research methodology news and research
  3. cassava7
    Thread

    Retraining and control therapy for pediatric psychogenic non-epileptic seizures (+ 1 year follow-up), Fobian et al, 2020

    Objective Our aim was to conduct a pilot randomized controlled trial of a novel cognitive behaviorally based intervention for pediatric PNES...
    Thread by: cassava7, Aug 8, 2022, 10 replies, in forum: Other psychosomatic news and research
  4. cassava7
    Thread

    A Double-Blind, Placebo-Controlled, Randomized, Clinical Trial of the TLR-3 Agonist Rintatolimod in Severe Cases of CFS, Strayer et al, 2012

    Background Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a severely debilitating disease of unknown pathogenesis consisting of a...
    Thread by: cassava7, Jul 28, 2022, 15 replies, in forum: ME/CFS research
  5. cassava7
    Thread

    Placebo effect: a psychosomatic component, or only an aggregate of other biases?

    We have previously discussed interventions that manipulate how patients report symptoms as a separate form of bias, rather than as part of the...
    Thread by: cassava7, Sep 27, 2021, 46 replies, in forum: Other health news and research
  6. Sly Saint
    Thread

    A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies, The AGReMA Statement, 2021, Lee et al

    Hopin Lee, PhD1,2; Aidan G. Cashin, PhD3,4; Sarah E. Lamb, DPhil1,5; Sally Hopewell, DPhil1; Stijn Vansteelandt, PhD6,7; Tyler J. VanderWeele,...
    Thread by: Sly Saint, Sep 25, 2021, 2 replies, in forum: Research methodology news and research
  7. Sly Saint
    Thread

    Article: New clinical trial aims to improve diagnosis, treatment and rehabilitation of long COVID

    A major new consortium involving the University of Exeter, has been awarded £6.8 million by the National Institute of Health Research (NIHR) to...
    Thread by: Sly Saint, Jul 18, 2021, 5 replies, in forum: Long Covid news
  8. DokaGirl
    Thread

    First Clinical Study of the Safety and Blood Levels of a Human Monoclonal Antibody (2217LS) Against Lyme Disease Bacteria in Healthy People

    First Clinical Study of the Safety and Blood Levels of a Human Monoclonal Antibody (2217LS) Against Lyme Disease Bacteria in Healthy People, 2021,...
    Thread by: DokaGirl, Jun 26, 2021, 1 replies, in forum: Infections: Lyme, Candida, EBV ...
  9. Sly Saint
    Thread

    ACT Randomized Controlled Trials since 1986 Submitted by Steven Hayes

    Given the rise in ACT 'research' this might be useful/of interest: Last updated: March 2021 The following information will be provided about...
    Thread by: Sly Saint, Apr 28, 2021, 0 replies, in forum: Other health news and research
  10. cassava7
    Thread

    The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 (...), Vinkers et al, 2021

    The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent...
    Thread by: cassava7, Apr 26, 2021, 4 replies, in forum: Research methodology news and research
  11. Three Chord Monty
    Thread

    Cognitive Behavioral Therapy Improves Physical Function & Fatigue in Mild & Moderate CFS: A Consecutive RCT, 2021, Gotaas et al

    Cognitive Behavioral Therapy Improves Physical Function and Fatigue in Mild and Moderate Chronic Fatigue Syndrome: A Consecutive Randomized...
    Thread by: Three Chord Monty, Apr 13, 2021, 100 replies, in forum: Psychosomatic research - ME/CFS and Long Covid
  12. Sly Saint
    Thread

    Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in ME/CFS: A Randomized, Double-Blind,Placebo-Controlled Trial,2021,Castro-Marrero

    Preprint Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized,...
    Thread by: Sly Saint, Apr 3, 2021, 62 replies, in forum: ME/CFS research
  13. rvallee
    Thread

    Outcome Reporting bias in Exercise Oncology trials (OREO): a cross-sectional study, 2021, Singh, Twomey et al

    Background Despite evidence of selective outcome reporting across multiple disciplines, this has not yet been assessed in trials studying the...
    Thread by: rvallee, Mar 15, 2021, 26 replies, in forum: Research methodology news and research
  14. Woolie
    Thread

    When is lack of scientific integrity a reason for retracting a paper? A case study.(2020) Fiedorowicz et al. (about homeopathy for CFS)

    When is lack of scientific integrity a reason for retracting a paper? A case study. Abstract: Objective: The present and past editors of this...
    Thread by: Woolie, Mar 3, 2021, 28 replies, in forum: Research methodology news and research
  15. Ryan31337
    Thread

    Randomized Trial of Ivabradine in Patients With Hyperadrenergic [POTS], 2021, Taub et al

    Background Postural orthostatic tachycardia syndrome (POTS) is a complex, multifaceted disorder that impairs functional status and quality of...
    Thread by: Ryan31337, Feb 18, 2021, 3 replies, in forum: Cardiovascular and exercise physiology (CPET)
  16. leokitten
    Thread

    Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19 A Randomized Clinical Trial. Lenze et al. JAMA (2020)

    An SSRI to treat early COVID, supposedly SSRIs can inhibit SARS-CoV-2 and also potentially have anti-inflammatory and immunoregulatory properties....
    Thread by: leokitten, Nov 13, 2020, 12 replies, in forum: Epidemics (including Covid-19, not Long Covid)
  17. MSEsperanza
    Thread

    The difficulties of conducting intervention trials for the treatment of [ME/CFS]: Expert testimony to NICE guidelines committee by Jonathan Edwards

    Thought it could be helpful to have a thread on Jonathan's expert testimony for any further use and citation. Edwards, Jonathan CW (2020), The...
    Thread by: MSEsperanza, Nov 12, 2020, 25 replies, in forum: Psychosomatic research - ME/CFS and Long Covid
  18. Sly Saint
    Thread

    Acceptability and Effectiveness of NHS-Recommended e-Therapies for Depression, Anxiety, and Stress: Meta-Analysis: Simmonds-Buckley 2020

    ABSTRACT Background: There is a disconnect between the ability to swiftly develop e-therapies for the treatment of depression, anxiety, and...
    Thread by: Sly Saint, Nov 7, 2020, 6 replies, in forum: Other psychosomatic news and research
  19. ME/CFS Skeptic
    Thread

    Why do doctors use treatments that do not work? Doust & Del Mar, 2005

    Thought this was an interesting editorial. It's from 2004 but is still relevant. The history of medicine is replete with examples of treatments...
    Thread by: ME/CFS Skeptic, Sep 18, 2020, 5 replies, in forum: Other health news and research
  20. ME/CFS Skeptic
    Thread

    What’s in the pipeline? Ongoing, registered, or planned clinical trials for ME/CFS

    Evelien and I were interested in what clinical trials are currently planned or ongoing for ME/CFS. It can take many years to conduct a clinical...
    Thread by: ME/CFS Skeptic, Sep 18, 2020, 33 replies, in forum: ME/CFS research
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