t cells

I’ve been reading/listening to lots about the immune system, particularly B and T cells. And thought it may be worth sharing some links to info I’ve found useful. If others have useful resources please chip in! There’s a lot of sources here and duplication, I found reading/listening to...

Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing Marta Līva Spriņģe; Kristīne Vaivode; Rihards Saksis; Nineļa Miriama Vainšeļbauma; Laura Ansone; Monta Brīvība; Helvijs Niedra; Vita Rovite Long-COVID affects at least 10% of COVID-19...

929 – Age-Dichotomous Associations of Long COVID With Frequency of Public SARS-CoV-2 Memory TCRs Selin Akbas, Shuai Li, Hao Zhang, Tamilore Adeagbo, Ni Zhao, Alan Landay, Michael Peluso, Elizabeth Thompson, Andrea Cox, Yukari Manabe, Hongkai Ji, Annukka Antar [Line breaks added] Background...

Clinical, histopathological, and radiological characterization of post-acute sequelae of COVID-19 Anna Czech Abstract Numerous patients exhibit enduring symptoms following a Coronavirus Disease 2019 (COVID-19) infection, termed Post-Acute Sequelae of COVID-19 (PASC). The typical manifestations...

Abstract Post-acute sequelae of COVID-19 (PASC) is a complex and multifaceted clinical challenge requiring to emphasize its underlying pathophysiological mechanisms. This study assessed hundreds of virological, serological, immunological, and tissue damage biomarkers in two patient cohorts who...

The neuroimmune connectome in health and disease Wheeler, Michael A.; Quintana, Francisco J. The nervous and immune systems have complementary roles in the adaptation of organisms to environmental changes. However, the mechanisms that mediate crosstalk between the nervous and immune systems...

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space Moreno-Villanueva, Maria; Jimenez-Chavez, Luis E.; Krieger, Stephanie; Ding, Liang-Hao; Zhang, Ye; Babiak-Vazquez, Adriana; Berres, Mark; Splinter...

Post-COVID-19 sequelae are associated with sustained SARS-CoV-2-specific CD4+ immune responses Venegoni; Raineri; Mazzucca; Ghazanfar; Cappellano; Baricich; Patrucco; Zeppegno; Gramaglia; Balbo; Cantaluppi; Patti; Giordano; Manfredi; Rolla; Sainaghi; Pirisi; Bellan; Chiocchetti BACKGROUND...

Identifying Neuro-inflammatory Biomarkers of Generalized Anxiety Disorder from Lymphocyte Subsets based on machine learning approaches Jingjing Lu, Weiwei Liang, Lijun Cui, Shaoqi Mou, Xuedan Pei, Xinhua Shen, Zhongxia Shen, Ping Shen Introduction Activation of the inflammatory response system...

Identification of an immunological signature of long COVID syndrome Guerrera, Gisella; Sambucci, Manolo; Timperi, Eleonora; Picozza, Mario; Misiti, Andrea; Placido, Roberta; Corbisiero, Silvia; D’Orso, Silvia; Termine, Andrea; Fabrizio, Carlo; Gargano, Francesca; Eleuteri, Sharon; Marchioni...

Abstract: The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks1,2,3. These dynamic regulatory circuits that respond to extracellular cues in primary human cells remain poorly defined. The...

Endogenous self-peptides guard immune privilege of the central nervous system Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F. M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe...

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients Shahbaz; Rezaeifar; Syed; Redmond; Terveart; Osman; Elahi A substantial portion of patients infected with SARS-CoV-2 experience prolonged complications...

Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities...

Nuclear factor kappa-B cell NF-κB, interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection Savitz; McKinney; Meier; Zheng; Ford; Yolken; Teague; Cole Altered activity of major immunoregulatory pathways has...

Maternal COVID-19 infection associated with offspring neurodevelopmental disorders Duan, Lian; Yin, Huamin; Liu, Jiaxin; Wang, Wenhang; Huang, Peijun; Liu, Li; Shen, Jingling; Wang, Zhendong Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring...

Abstract The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) was used to...

SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years Rowntree, Louise C.; Audsley, Jennifer; Allen, Lilith F.; McQuilten, Hayley A.; Hagen, Ruth R.; Chaurasia, Priyanka; Petersen, Jan; Littler, Dene R.; Tan...

An aberrant immune–epithelial progenitor niche drives viral lung sequelae Narasimhan, Harish; Cheon, In Su; Qian, Wei; Hu, Sheng’en Shawn; Parimon, Tanyalak; Li, Chaofan; Goplen, Nick; Wu, Yue; Wei, Xiaoqin; Son, Young Min; Fink, Elizabeth; de Almeida Santos, Gislane; Tang, Jinyi; Yao, Changfu...

Epigenetic patterns, accelerated biological aging, and enhanced epigenetic: drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study, 2024, Calzari Luciano, Dragani Davide Fernando et al Abstract Background The epigenetic status of patients 6-month...