t cells

The neuroimmune connectome in health and disease Wheeler, Michael A.; Quintana, Francisco J. The nervous and immune systems have complementary roles in the adaptation of organisms to environmental changes. However, the mechanisms that mediate crosstalk between the nervous and immune systems...

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space Moreno-Villanueva, Maria; Jimenez-Chavez, Luis E.; Krieger, Stephanie; Ding, Liang-Hao; Zhang, Ye; Babiak-Vazquez, Adriana; Berres, Mark; Splinter...

Post-COVID-19 sequelae are associated with sustained SARS-CoV-2-specific CD4+ immune responses Venegoni; Raineri; Mazzucca; Ghazanfar; Cappellano; Baricich; Patrucco; Zeppegno; Gramaglia; Balbo; Cantaluppi; Patti; Giordano; Manfredi; Rolla; Sainaghi; Pirisi; Bellan; Chiocchetti BACKGROUND...

Identifying Neuro-inflammatory Biomarkers of Generalized Anxiety Disorder from Lymphocyte Subsets based on machine learning approaches Jingjing Lu, Weiwei Liang, Lijun Cui, Shaoqi Mou, Xuedan Pei, Xinhua Shen, Zhongxia Shen, Ping Shen Introduction Activation of the inflammatory response system...

Identification of an immunological signature of long COVID syndrome Guerrera, Gisella; Sambucci, Manolo; Timperi, Eleonora; Picozza, Mario; Misiti, Andrea; Placido, Roberta; Corbisiero, Silvia; D’Orso, Silvia; Termine, Andrea; Fabrizio, Carlo; Gargano, Francesca; Eleuteri, Sharon; Marchioni...

Abstract: The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks1,2,3. These dynamic regulatory circuits that respond to extracellular cues in primary human cells remain poorly defined. The...

Endogenous self-peptides guard immune privilege of the central nervous system Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F. M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe...

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients Shahbaz; Rezaeifar; Syed; Redmond; Terveart; Osman; Elahi A substantial portion of patients infected with SARS-CoV-2 experience prolonged complications...

Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities...

Nuclear factor kappa-B cell NF-κB, interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection Savitz; McKinney; Meier; Zheng; Ford; Yolken; Teague; Cole Altered activity of major immunoregulatory pathways has...

Maternal COVID-19 infection associated with offspring neurodevelopmental disorders Duan, Lian; Yin, Huamin; Liu, Jiaxin; Wang, Wenhang; Huang, Peijun; Liu, Li; Shen, Jingling; Wang, Zhendong Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring...

Abstract The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) was used to...

SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years Rowntree, Louise C.; Audsley, Jennifer; Allen, Lilith F.; McQuilten, Hayley A.; Hagen, Ruth R.; Chaurasia, Priyanka; Petersen, Jan; Littler, Dene R.; Tan...

An aberrant immune–epithelial progenitor niche drives viral lung sequelae Narasimhan, Harish; Cheon, In Su; Qian, Wei; Hu, Sheng’en Shawn; Parimon, Tanyalak; Li, Chaofan; Goplen, Nick; Wu, Yue; Wei, Xiaoqin; Son, Young Min; Fink, Elizabeth; de Almeida Santos, Gislane; Tang, Jinyi; Yao, Changfu...

Epigenetic patterns, accelerated biological aging, and enhanced epigenetic: drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study, 2024, Calzari Luciano, Dragani Davide Fernando et al Abstract Background The epigenetic status of patients 6-month...

The longitudinal characterization of immune responses in COVID-19 patients reveals novel prognostic signatures for disease severity, patients’ survival and long COVID Noviello, Maddalena; De Lorenzo, Rebecca; Chimienti, Raniero; Maugeri, Norma; De Lalla, Claudia; Siracusano, Gabriel; Lorè...

Bioinformatic analysis predicts the regulatory function of noncoding SNPs associated with Long COVID-19 syndrome Maiti, Amit K. Long or Post COVID-19 is a condition of collected symptoms persisted after recovery from COVID-19. Host genetic factors play a crucial role in developing Long...

Sex differences and immune correlates of Long COVID development, persistence, and resolution Rebecca E Hamlin; Shaun M Pienkos; Leslie Chan; Mikayla A Stabile; Kassandra Pinedo; Mallika Rao; Philip Grant; Hector Bonilla; Marisa Holubar; Upinder Singh; Karen B Jacobson; Prasanna Jagannathan...

Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome Saito; Shahbaz; Osman; Redmond; Bozorgmehr; Rosychuk; Lam; Sligl; Cohen Tervaert; Elahi A substantial number of patients recovering from acute SARS-CoV-2...

Our next @RenegadeRes Research roundtable is Thursday May 23rd. The topic is "T-cell dysfunction in #MECFS and #LongCovid " with researchers Liisa K. Selin, MD PhD; Anna Gil, PhD, viral immunologists from the University of Massachusetts Chan Medical School Roshan Kumar, PhD,… Show more...