t cells

Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID. Lucie Rodriguez; Ziyang Tan; Lakshmi Kanth Tadepally; Jun Wang; Hugo Barcenilla; Zoe Swank; Fanglei Zuo; Hassan Abolhassani; Ana Jimena Pavlovitch-Bedzyk; Chunlin Wang...

Genome-wide association study reveals different T cell distributions in peripheral blood of healthy individuals at high genetic risk of type 1 diabetes and long COVID Laura Deecke; Jan Homann; David Goldeck; Felix Luessi; Marijne Vandebergh; Olena Ohlei; Sarah Toepfer; Frauke Zipp; Ilja Demuth...

Abstract Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease, relatively little is known about the precise nature of the immune dysregulation underlying the development of the disease. Reasoning that the CSF from patients might be enriched for cells relevant in...

Persistent CD8+ T cell proliferation and activation in COVID-19 adult survivors with post-acute sequelae: a longitudinal, observational cohort study of persistent symptoms and T cell markers LaVergne, Stephanie M.; Dutt, Taru S.; McFann, Kim; Webb, Tracy L.; Henao-Tamayo, Marcela; Ryan...

Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis Abstract Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail...

Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells Significance On average, 13% of the T lymphocytes in the cerebrospinal fluid of people with the first symptoms of multiple sclerosis are specific for autologous...

Highlights 76 bacterial species of 15 genera across healthy, COVID-19-positive, and recovered individuals Higher abundance of opportunistic intracellular bacteria in recovered group Higher microbial abundance within antigen-presenting cells of COVID-19 patients Differential microbial abundance...

I wasn't sure what prefix to use given that the paper has been accepted in Cell but not published. I read about it in a paywalled news article as the abstract was presented at the ECTRIMS 2023. Ineffective Immune Control of Epstein-Barr Virus-Induced Autoreactive Responses is an Important Cause...

Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans Abstract Chikungunya virus (CHIKV) is a mosquito-borne re-emerging viral infection that can cause chronic chikungunya viral arthritic disease (CHIKVD), which is characterized by...

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes undetectable in upper airways after a few days or weeks postinfection. Here we used a model of viral...

Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID Kaiming Wang; Mobin Khoramjoo; Karthik Srinivasan; Paul M.K. Gordon; Rupasri Mandal; Dana Jackson; Wendy Sligl; Maria B. Grant; Josef M. Penninger; Christoph H. Borchers; David S. Wishart...

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with...

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition Limoges, Marc-André; Quenum, Akouavi Julite Irmine; Chowdhury, Mohammad Mobarak Hussain; Rexhepi, Fjolla; Namvarpour, Mozhdeh...

The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion Abstract CD8+ T cells are essential components of the immune response against viral infections and tumours, and are capable of eliminating infected and cancerous cells. However, when the antigen cannot be cleared, T cells...

Abstract The long-term health effects of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are quickly evolving into a major public health concern, but the underlying cellular and molecular etiology remain poorly defined. There is growing evidence that PASC is linked to abnormal immune...

BACKGROUND. Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis (LA). However, the identity of...

SARS-CoV-2-specific T cell therapy for severe COVID-19: a randomized phase 1/2 trial Abstract Despite advances, few therapeutics have shown efficacy in severe coronavirus disease 2019 (COVID-19). In a different context, virus-specific T cells have proven safe and effective. We conducted a...

Abstract Glaucoma is the leading cause of irreversible blindness. Currently, most therapeutic strategies aim to reduce elevated intraocular pressure (EIOP), but this does not always halt disease progression. Evidence suggests a role for T cells in glaucoma pathogenesis, but the underlying...

Abstract: Millions globally suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The inflammatory symptoms, illness onset, recorded outbreak events, and physiological variations provide strong indications that ME/CFS, at least sometimes, has an infectious origin, possibly...