Oxidative Stress is a shared characteristic of ME/CFS and Long COVID
Vishnu Shankar; Julie Wilhelmy; Basil Michael; Layla Cervantes; Vamsee Mallajosyula; Ronald Davis; Michael Snyder; Shady Younis; William H Robinson; Sadasivan Shankar; Paul Mischel; Hector Bonilla; Mark Davis
More than 65...
calcium
glutathione
gpx4
lipid droplets
lipids
mark davis
metformin
mitochondria
oxidative stress
reactive oxygen species
ron davis
sex differences
tcells
https://www.nature.com/articles/s41392-023-01471-y
Very long article
Abstract
T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and mainly generates CD4+ and CD8+ T cell subsets. Upon antigen...
n=31
Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection
Abstract
This study investigates the humoral and cellular immune responses and health-related quality of life measures in individuals with mild to moderate long COVID (LC)...
Systems analysis of innate and adaptive immunity in Long COVID
Peluso; Abdel-Mohsen; Henrich; Roan
Since the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the...
Sex differences in symptomatology and immune profiles of Long COVID
Julio Silva; Takehiro Takahashi; Jamie Wood; Peiwen Lu; Sasha Tabachnikova; Jeffrey Gehlhausen; Kerrie Greene; Bornali Bhattacharjee; Valter Silva Monteiro; Carolina Lucas; Rahul Dhodapkar; Laura Tabacof; Mario Pena-Hernandez...
april
cmv
complement
cortisol
dendritic cells
ebv
endocrine
endocrine regulation
hsv2
immune system
interferon
long covid
monocytes
nk cells
oestrogen
sex differences
tcellstestosterone
Preprint
Blood-brain barrier disruption in Long COVID-associated cognitive impairment
Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell
Vascular disruption has been...
Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID.
Lucie Rodriguez; Ziyang Tan; Lakshmi Kanth Tadepally; Jun Wang; Hugo Barcenilla; Zoe Swank; Fanglei Zuo; Hassan Abolhassani; Ana Jimena Pavlovitch-Bedzyk; Chunlin Wang...
Genome-wide association study reveals different T cell distributions in peripheral blood of healthy individuals at high genetic risk of type 1 diabetes and long COVID
Laura Deecke; Jan Homann; David Goldeck; Felix Luessi; Marijne Vandebergh; Olena Ohlei; Sarah Toepfer; Frauke Zipp; Ilja Demuth...
Abstract
Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease, relatively little is known about the precise nature of the immune dysregulation underlying the development of the disease.
Reasoning that the CSF from patients might be enriched for cells relevant in...
Persistent CD8+ T cell proliferation and activation in COVID-19 adult survivors with post-acute sequelae: a longitudinal, observational cohort study of persistent symptoms and T cell markers
LaVergne, Stephanie M.; Dutt, Taru S.; McFann, Kim; Webb, Tracy L.; Henao-Tamayo, Marcela; Ryan...
Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
Abstract
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail...
Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells
Significance
On average, 13% of the T lymphocytes in the cerebrospinal fluid of people with the first symptoms of multiple sclerosis are specific for autologous...
Highlights
76 bacterial species of 15 genera across healthy, COVID-19-positive, and recovered individuals
Higher abundance of opportunistic intracellular bacteria in recovered group
Higher microbial abundance within antigen-presenting cells of COVID-19 patients
Differential microbial abundance...
I wasn't sure what prefix to use given that the paper has been accepted in Cell but not published. I read about it in a paywalled news article as the abstract was presented at the ECTRIMS 2023.
Ineffective Immune Control of Epstein-Barr Virus-Induced Autoreactive Responses is an Important Cause...
Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans
Abstract
Chikungunya virus (CHIKV) is a mosquito-borne re-emerging viral infection that can cause chronic chikungunya viral arthritic disease (CHIKVD), which is characterized by...
Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants
Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...
SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes undetectable in upper airways after a few days or weeks postinfection. Here we used a model of viral...
Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID
Kaiming Wang; Mobin Khoramjoo; Karthik Srinivasan; Paul M.K. Gordon; Rupasri Mandal; Dana Jackson; Wendy Sligl; Maria B. Grant; Josef M. Penninger; Christoph H. Borchers; David S. Wishart...
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with...
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