t cells

  1. Mij

    Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19, 2023, Harish Narasimhan et al

    Abstract The long-term health effects of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are quickly evolving into a major public health concern, but the underlying cellular and molecular etiology remain poorly defined. There is growing evidence that PASC is linked to abnormal immune...
  2. Mij

    Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis, 2023, Korawit Kanjana et al

    BACKGROUND. Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis (LA). However, the identity of...
  3. E

    SARS-CoV-2-specific T cell therapy for severe COVID-19: a randomized phase 1/2 trial, 2023, Yannaki et al

    SARS-CoV-2-specific T cell therapy for severe COVID-19: a randomized phase 1/2 trial Abstract Despite advances, few therapeutics have shown efficacy in severe coronavirus disease 2019 (COVID-19). In a different context, virus-specific T cells have proven safe and effective. We conducted a...
  4. Sly Saint

    Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma 2023, Chong He et al

    Abstract Glaucoma is the leading cause of irreversible blindness. Currently, most therapeutic strategies aim to reduce elevated intraocular pressure (EIOP), but this does not always halt disease progression. Evidence suggests a role for T cells in glaucoma pathogenesis, but the underlying...
  5. Sly Saint

    Review Surveying the Metabolic and Dysfunctional Profiles of T Cells and NK Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 2023, Maya

    Abstract: Millions globally suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The inflammatory symptoms, illness onset, recorded outbreak events, and physiological variations provide strong indications that ME/CFS, at least sometimes, has an infectious origin, possibly...
  6. T

    Preprint Comparison of T-cell Receptor Diversity of people with Myalgic Encephalomyelitis versus controls, 2023, Dibble, Ponting et al

    Pre-print Free fulltext: https://www.researchsquare.com/article/rs-3164397/v1 Comparison of T-cell Receptor Diversity of people with Myalgic Encephalomyelitis versus controls Joshua J Dibble1 Ben Ferneyhough2 Matthew Roddis2 Sam Millington2 Michael D Fischer2 Nick J Parkinson2 Chris P...
  7. Hutan

    IIMEC 2023: Maureen Hanson

    IIMEC15 08 Professor Maureen Hanson 15th Invest in ME Research International ME Conference 2023 29 minutes Terrific presentation from Professor Maureen Hanson including some unpublished work I think we are getting close to some real answers - exhausted t-cells, abnormal classical monocytes...
  8. John Mac

    Divergent adaptive immune responses define two types of Long COVID, 2023, Chakrabarti et al

    The role of adaptive immune responses in long COVID remains poorly understood, with contrasting hypotheses suggesting either an insufficient antiviral response or an excessive immune response associated with inflammatory damage. To address this issue, we set to characterize humoral and CD4+ T...
  9. SNT Gatchaman

    [Preprint] Trained immunity in human monocyte enhances myeloid-T-cell pathogenic crosstalk in Ankylosing Spondylitis, 2023, Zhao et al.

    Trained immunity in human monocyte enhances myeloid-T-cell pathogenic crosstalk in Ankylosing Spondylitis Jinyi Zhao; Feng Liu; Claudia Worth; Davide Simone; Frank Penkava; Hui Shi; Jiaqi Li; Shristi Lama; Hai Fang; Jeong Seok Lee; Tae-Jong Kim; Lihua Duan; Paul Bowness; Liye Chen Recent...
  10. SNT Gatchaman

    Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19, 2023, Sparks et al

    Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19 Sparks R, Lau WW, Liu C, Han KL, Vrindten KL, Sun G, Cox M, Andrews SF, Bansal N, Failla LE, Manischewitz J, Grubbs G, King LR, Koroleva G, Leimenstoll S, Snow L; OP11 Clinical Staff; Chen J, Tang J, Mukherjee A, Sellers...
  11. Andy

    Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2 2023 Yin et al

    Abstract Long COVID (LC), a type of post-acute sequelae of SARS-CoV-2 infection (PASC), occurs after at least 10% of SARS-CoV-2 infections, yet its etiology remains poorly understood. Here, we used multiple omics assays (CyTOF, RNAseq, Olink) and serology to deeply characterize both global and...
  12. B

    Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2023, Maya et al

    https://www.mdpi.com/1422-0067/24/3/2010 Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling multisystem illness in which individuals are plagued with fatigue, inflammatory symptoms, cognitive dysfunction, and the hallmark symptom, post-exertional malaise. While...
  13. S

    Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, 2022, Finlay JB

    Abstract: SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy studies have suggested...
  14. cassava7

    BBC News: Base editing: Revolutionary therapy clears girl's incurable cancer

    Alyssa, who is 13 and from Leicester, was diagnosed with T-cell acute lymphoblastic leukaemia in May last year. (…) Base editing allows scientists to zoom to a precise part of the genetic code and then alter the molecular structure of just one base, converting it into another and changing the...
  15. John Mac

    Tevogen Bio to investigate T cell therapy in long Covid

    Tevogen Bio is set to study the potential therapeutic use of its investigational Covid-19 T cell therapy, TVGN-489, in long Covid. The finding that none of the patients in the TVGN 489 proof-of-concept (POC) trial, treated for their initial Covid infection, developed long Covid to date is...
  16. cassava7

    Phenotypic characteristics of peripheral immune cells of ME/CFS via transmission electron microscopy: A pilot study, Jahanbani et al, 2022

    Fereshteh Jahanbani, Rajan D. Maynard, Justin Cyril Sing, Shaghayegh Jahanbani, John J. Perrino, Damek V. Spacek, Ronald W. Davis, Michael P. Snyder Received: January 17, 2022; Accepted: July 25, 2022; Published: August 9, 2022 — Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is...
  17. SNT Gatchaman

    Recovering or Persisting: The Immunopathological Features of SARS-CoV-2 Infection in Children, 2022, Buonsenso et al

    Recovering or Persisting: The Immunopathological Features of SARS-CoV-2 Infection in Children Buonsenso D, Valentini P, De Rose C, Tredicine M, Pereyra Boza MdC, Camponeschi C, Morello R, Zampino G, Brooks AES, Rende M, Ria F, Sanguinetti M, Delogu G, Sali M, Di Sante G, on behalf of the...
  18. SNT Gatchaman

    Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology, 2022, Hejbøl et al

    Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology Eva K Hejbøl, Thomas Harbo, Jane Agergaard, Line B Madsen, Thomas H Pedersen, Lars J Østergaard, Henning Andersen, Henrik D Schrøder, Hatice Tankisi Background: Among post-COVID-19...
  19. SNT Gatchaman

    Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers, 2022

    Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers Miguel Galan, Lorena Vigon, Daniel Fuertes, Marıa Aranzazu Murciano-Anton, Guiomar Casado-Fernandez, Susana Domınguez-Mateos, Elena Mateos, Fernando...
  20. Sean

    Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2, 2021, Leo Swadling et al

    Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 Leo Swadling, et al. Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells...
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