A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

By Open Medicine Foundation

full article here:
https://www.sanluisobispo.com/news/state/california/article229756099.html

[have looked at the link but can't find the published paper?]
eta: link now works
this one takes you to where it's listed
https://www.pnas.org/search/chronic%2Bfatigue%2Bsyndrome content_type:journal

eta2: paper here
https://www.pnas.org/content/early/2019/04/24/1901274116

Sci hub, https://sci-hub.se/10.1073/pnas.1901274116

 

I would guess from this

that that link will be updated later today at some point, with this and all other papers published today - it's still early morning US time.

 

The biggest concern i have is is the small patient size.
They need to verify this on a sample of thousands or tens of thousands before it should be considered a diagnostic test.
Of course there are cost and logistical issues involved in doing this but if this test turns out to be wrong the damage done will be immense.

 

I wonder if it turns out to be right, how long will it take to get it approved. Has anyone any idea how long this kind of thing takes.. I know funding is a huge factor.

 

It also has to be tested on other complex illnesses to see if it's unique to ME.

Perhaps there are drugs that are already available.

 

It has to be tested on other illnesses where “fatigue” is one of the main simptoms.

Even if it was a Test for PEM, it would be amazing. Time to apply for a NIH grant !!!

 

I'm going to hold off judgement until we know how significant the result was and how many parameters were measured in search of a significant looking one.

 

Excited to see this. PNAS is a high-impact journal and is of course multidisciplinary, which is an advantage.

I worry with all the pressure on Ron and his team that they may try and rush things through. On the other hand, they are top-class scientists and know what they are doing.

 

Is the article gone?

 

It's gone. They had a premature publication.

 

The article is gone. I also can't find anything on National Academy of Sciences. I know Ron Davis said this piece was coming out soon but not sure what's going on. I'd love to share the headline far and wide!

 

As far as I can tell, and unless something else is going on, the paper is embargoed until 3 pm ET. I imagine the news article should have respected that embargo and that is the reason why it has disappeared.

 

@InitialConditions

I too worry about the pressure on the OMF, and Ron Davis. They are as you say top professionals. Another thing going for them is networking with other research groups. Hopefully that removes some of the pressure.

 

EurekAlert: Biomarker for chronic fatigue syndrome identified by Stanford researchers

 

Stanford Medicine: Biomarker for chronic fatigue syndrome identified

https://twitter.com/user/status/1122941374540726272

 

https://www.pnas.org/content/early/2019/04/24/1901274116

Here is the paper. Subscription required.

 

Sci hub, https://sci-hub.se/10.1073/pnas.1901274116

 

More news:
https://medicalxpress.com/news/2019-04-biomarker-chronic-fatigue-syndrome.amp

By Miriam E. Tucker: https://www.medscape.com/viewarticle/912336

With lots of quotes from experts: https://www.sfchronicle.com/bayarea/amp/Stanford-discovery-validates-chronic-fatigue-13804385.php

Over in Ireland: http://www.irishnews.com/magazine/s...c-fatigue-syndrome-may-be-on-its-way-1608816/

And the bad... (both archived so they don't get hits)

KK's version: https://web.archive.org/web/https://uk.mobile.reuters.com/article/amp/idUKKCN1S51X9

Telegraph: http://web.archive.org/web/20190429...-syndrome-may-picking-symptoms-not-condition/

 

From Reuters. The second part seems irrelevant to me. Even if it's measuring a consequence of the illness, rather than its cause, it can still be a biomarker?

ETA: It's SW commenting.