A Unifying Hypothesis of the Pathophysiology of (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors: Wirth 2020

I think I might be able to demonstrate with a simple test that there is a circulatory problem.

If I stand on my feet and reach down to pet my cat, and then after 10 or 20 seconds bring the head back up, I feel unwell (dizzy, malaise, weak). If I repeat this posture change (giving the body some time to adjust to each change) then it gets increasingly worse. After a few times I'm visibly weak and slow so much that it cannot be missed by an outside observer.

 

I find that any repeated movement can reduce me to a paralysed lump eventually. The definition of ME as a disease where you can lift a bag of potatoes over your head once but not lift a spoon to your mouth five times captures much of my disability but does not seem to be well known among scientists and researchers.

 

Cort Johnson just posted a blog about this study:

http://simmaronresearch.com/2020/05/blood-vessel-crunch-chronic-fatigue-syndrome/

 

That url is no longer working. It's now here:

https://www.simmaronresearch.com/blog/2020/05/blood-vessel-crunch-chronic-fatigue-syndrome

 

sci hub link

https://www.sci-hub.ee/10.1016/j.autrev.2020.102527

 

The original link from the opening post is open access now. Here's the link again, to save you going back:

https://www.sciencedirect.com/science/article/pii/S1568997220300823

There's also a followup paper:

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02833-2

discussed here:

https://www.s4me.info/threads/patho...ces-in-me-cfs-2021-wirth-scheibenbogen.20256/