Review Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Komaroff et al.

ME Research UK:

A review by Prof. Anthony Komaroff and Prof. Robert Dantzer, has highlighted that ME/CFS and long COVID may share common biological abnormalities that directly cause symptoms of both illnesses. Interestingly, several of the underlying abnormalities appear to reinforce each other and lead to persisting “vicious cycles” of illness and disease.

Note : ME/CFS is a symptom-based clinical diagnosis not a mechanistic one. It is clear there is a high degree of shared pathophysiology between the ME/CFS and long COVID and the two diagnostic labels are not mutually exclusive.

Read more: http://bit.ly/4lu3oQD
 
Margaret Williams has written about this paper:

2026
1 Sep 2026Short Synopsis of paper by Dr Anthony Komaroff and Dr Robert Dantzer (2025)Margaret WilliamsPDF

I had no idea that she also wrote a response to @Jonathan Edwards theory paper "A Proposed Mechanism for ME/CFS Invoking Macrophage FcɣRI and Interferon Gamma"

Articles on ME/CFS by Professor Malcolm Hooper and Margaret Williams

Articles by Margaret Williams and Prof Malcolm Hooper. A valuable historical resource for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, ME/CFS
margaretwilliams.me


2025
24 Dec 2025Severe Gastrointestinal Failure and the Necessity of Total Parenteral Nutrition in ME/CFS (leaflet)Dr William Weir and Jenny WilsonPDF
6 Oct 2025Update on Wessely's Words of WisdomMargaret WilliamsPDF
21 Sep 2025What is PEM in Myalgic Encephalomyelitis?Margaret WilliamsPDF
17 Sep 2025Regius Professor Sir Simon Wessely Proved Wrong Yet AgainMargaret WilliamsPDF
12 Sep 2025Is Elsevier Guilty of Misinformation about ME?Margaret WilliamsPDF
6 Jul 2025Has there been Scientific Misconduct regarding ME in the UK?Margaret WilliamsPDF
28 Jun 2025Historic Evidence of the Organicity of ME ("Grey Information" Update)Margaret WilliamsPDF
17 Jun 2025Information Underlying the Request for Forfeiture of the Honours Bestowed on Professor Sir Simon WesselyMargaret WilliamsPDF
30 May 2025Response to Jo EdwardsMargaret WilliamsPDF
26 May 2025Wessely's Words of WisdomMargaret WilliamsPDF
 
Last edited:
Chandelier said:
I had no idea that she also wrote a response to @Jonathan Edwards theory paper "A Proposed Mechanism for ME/CFS Invoking Macrophage FcɣRI and Interferon Gamma"
Click to expand...
Seems like forestglip found it back then:
forestglip

Preprint Post in thread 'A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff'

@Jonathan Edwards, I'm not sure if you saw this response from Margaret Williams. She posted it on her website (PDF), and someone also shared it on Phoenix Rising:

forums.phoenixrising.me

DISCUSSION: Prof. Johnathan Edwards, MD: "A Proposed Mechanism for ME/CFS Invoking Macrophage FcγRI and Interferon Gamma"

A Proposed Mechanism for ME/CFS Invoking Macrophage FcγRI and Interferon Gamma Jonathan Edwards1, Geraldine Cambridge1, Jacqueline M Cliff2 Abstract Evidence bearing on possible mechanisms for the clinical syndrome of ME/CFS is reviewed. The evidence is used to argue for a hypothesis that...
forums.phoenixrising.me forums.phoenixrising.me

First few paragraphs:
Professor Emeritus Jonathan Edwards states in his Qeios Review Article: “The absence of structural or biochemical pathology in ME/CFS has meant that definition is based entirely on symptoms and their dynamics over...
Click to expand...
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