Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging, 2026, Bedard, Nath, Walitt+

DMissa said:
It would be good to get eyes on that study that are well enough equipped to scrutinise the data and the claim
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Was it this paper?
SNT Gatchaman

Thread 'ME/CFS and Long COVID Demonstrate Similar Bioenergetic Impairment and Recovery Failure on Two-Day Cardiopulmonary Exercise Testing, 2026, Davenport+'

Now published, see post #27.

ME/CFS and Long COVID Demonstrate Similar Bioenergetic Impairment and Recovery Failure on Two-Day Cardiopulmonary Exercise Testing
Todd Davenport; Staci Stevens; Jared Stevens; Mark Van Ness


Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long Covid are characterized by post-exertional malaise (PEM). Similarities in disease presentation suggest important commonalities in bioenergetic impairment, but this hypothesis has not been demonstrated. The metabolic underpinnings of each disease can be elucidated by two...
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SNT Gatchaman said:
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating chronic disease characterized by physical and mental fatigue, post-exertional malaise, muscle pain, headaches, and unrefreshing sleep
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Boy, this sounds like such a boring illness. Delete "debilitating", and I'm left with a yawn - especially with the silly underscoring of fatigue (yet again). I cannot believe they still don't get it. In fact, I don't believe it.

This has the feel of another NIH escapade.

If you're going to embrace researching a disease, please start off by characterizing it accurately and exhaustively - preferably without the minimalist speak. And sans Nath/Walitt. In fact, there should be a patient committee empowered with oversight privileges into study principals and direction.
 
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chillier said:
They say no change in muscle/brain activity in mecfs causes fatigue. To me it seems more likely that the patients experienced fatigue faster therefore the experiment was over before any muscle fatigue or brain activity in the TPJ etc ever have the need to kick in.
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Yeah was thinking the same. Perhaps the most interesting things happened before those fatigue blocks in ME/CFS patients.

Think the experiment is interesting, but with only 15 patients and so many tests, it's hard to make conclusions. Would be interesting to see how other controls, such as patients with myasthenia gravis or depression, fare on these measures.
 
SNT Gatchaman said:
my first question around these findings would be: is this a trained outcome for a central nervous system that has long adapted to rapid (peripheral) neuromuscular fatiguability?
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I agree with this.

Neurologist Michael Stingl said the following:

"What this study does not show: that ME/CFS "originates" in the brain. The lack of adaptation can also have peripheral causes, which lead to a reaction of the brain to problems elsewhere in the body - but these were not investigated.

PEM was not measure."

 
I'm wondering how this would fit with orthostatic intolerance? It seems to me that OI is more than muscle fatigue (eg postural tachycardia can be worse standing than walking). So a central issue reducing adaption to both muscle action or a change to upright position (or indeed to cognitive demands) makes sense to my unscientific brain.

Would be good to see this tested further against other cohorts too.
 
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