Disrupted Glymphatic Function and Its Relationship with Sleep and Cognitive Impairment in ME/CFS Assessed via DTI-ALPS, 2026, Marshall-Gradisnik et al

[Nitro802]

This forum is a real godsend for people like me because it keeps me from harboring any illusions. This article caused a real stir on Reddit and Twitter. Everyone is excited about it. You just have to come here to be brought right back down to earth and fall into despair all over again, haha.

I came here to post this exact same thing. I saw the big hype on reddit, (this mechanism resonates with me, as I feel hungover and feel like my body/brain just doesn't repair overnight, unrefreshing sleep was my first symptom) and came to check here to understand if this actually had some legs. Very grateful this forum and it's smart contributors exist.

 

[Creekside]

Re-read the abstract, but replace "glymphatic function" with "restaurant spending". I'm pretty sure that a study would show that PWME spend less in restaurants than healthy controls (we feel too lousy to enjoy the experience, plus risk of PEM). It's easy enough to claim that less spending in restaurants "may lead to symptoms such as cognitive dysfunction and sleep disturbance experienced by ME/CFS." Spending probably correlates with severity, and probably also has a gender bias, supporting the theory. How difficult would it be to firmly disprove that theory?

It's far too easy, and without serious drawbacks, to publish studies or theories that promise an easy fix, which gets some people excited.