Evidence for a genetic component in ME/CFS - discussion thread

ME/CFS Skeptic · Aug 4, 2020

Simon M said: ↑

there is a review paper in press that looks at these issues and might be available quite soon.
Click to expand...

Oh wow thanks. Congrats with the paper!

Relevant section from the paper:

Evidence that CFS risk is inherited

Various observations are consistent with genetic factors contributing to CFS risk for some individuals. Individuals with a CFS diagnosis (Fukuda or ICD-9 code 780.71 criteria) have a significant excess relatedness over the wider population for both close (first or second degree) and distant (third degree) relatives (16, 22). Of three studies that have estimated narrow-sense heritability (h 2 ) using large cohorts, two reported non-zero h 2 -values that provide evidence for heritability of risk for CFS and, presumably, ME/CFS. An analysis of USA health insurance claimed a high narrow-sense heritability ( ) of CFS (23) whereas an analysis of UK Biobank individuals self-reporting a CFS diagnosis reported a less striking heritability (single nucleotide polymorphism- [SNP-] based approximate h 2 = 0.08 with low confidence) (24, http://www.nealelab.is/uk-biobank). The third, a large twin-based study of CFS-like cases, produced an inconclusive result, with the 95% confidence interval of h 2 including zero [0.03 (0.00–0.65)] (25).
Click to expand...

ME/CFS Skeptic · Aug 4, 2020

Jonathan Edwards said: ↑

I thought there was some recent information from a big epidemiological study in California that happened to check for CFS linkage. Again, Simon would know.
Click to expand...

Perhaps it was this study by Lakhani et al., that came out last year: https://www.s4me.info/threads/repur...ns-in-560-phenotypes-2019-lakhani-et-al.7675/

Sly Saint · Sep 6, 2021

Genetic Predisposition and Abnormalities of ME/CFS
By
Adrienne Dellwo

Updated on September 05, 2021
https://www.verywellhealth.com/chronic-fatigue-syndrome-genetics-5093946

Log in or Sign up

Evidence for a genetic component in ME/CFS - discussion thread

ME/CFS Skeptic Senior Member (Voting Rights)

ME/CFS Skeptic Senior Member (Voting Rights)

Sly Saint Senior Member (Voting Rights)

Share This Page

Log in or Sign up

Evidence for a genetic component in ME/CFS - discussion thread

ME/CFS Skeptic Senior Member (Voting Rights)

ME/CFS Skeptic Senior Member (Voting Rights)

Sly Saint Senior Member (Voting Rights)

Share This Page

Useful Searches