Examination of autoantibodies to type I interferon in patients suffering from long COVID, 2023, Hansen et al.

Discussion in 'Long Covid research' started by SNT Gatchaman, Sep 18, 2023.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

    Aotearoa New Zealand
    Examination of autoantibodies to type I interferon in patients suffering from long COVID
    Kristoffer Skaalum Hansen; Sofie Eg Jørgensen; Morten Kelder Skouboe; Jane Agergaard; Berit Schiøttz-Christensen; Line Khalidan Vibholm; Martin Tolstrup; Lars Østergaard; Steffen Leth; Trine H. Mogensen

    Long COVID (LC) is an emerging global health concern. The underlying mechanism and pathophysiology remain unclear. Presence of neutralizing autoantibodies against type 1 interferons (IFN) has been established as a predictor of critical COVID‐19. We hypothesized that persistent autoimmune activity with autoantibodies against type 1 IFN may contribute to symptoms in patients with LC.

    Plasma samples and clinical information were obtained from a Danish LC cohort consisting of adult patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Information on symptoms and quality of life was derived from an LC‐specific questionnaire and the EQ‐5D‐5L questionnaire. Detection of type 1 IFN autoantibodies in plasma were performed by ELISA. Samples collected between June, 2020, and September, 2021, from 279 patients were analyzed and compared to a control group of 94 individuals with prior mild SARS‐CoV‐2 infection who did not develop LC symptoms.

    In total, five LC patients (1.8%) and 3 (3.2%) of the controls had detectable circulating type 1 IFN autoantibodies. Collectively, prevalence of autoantibodies against type 1 IFN subtypes in our LC cohort were primarily driven by men and did not exceed the prevalence in controls. Thus, in our cohort, anti‐type I IFN autoantibodies are unlikely to drive LC symptoms.

    Link | Paywalled (Journal of Medical Virology)
    MEMarge, Trish, EndME and 5 others like this.
  2. Hutan

    Hutan Moderator Staff Member

    Aotearoa New Zealand
    Nice to see a null result stated clearly in the abstract. Assuming the methodology was good, this paper moves our knowledge of Long covid forward.
    alktipping, Trish, Milo and 3 others like this.

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