Hydroxyproline elevated in ME/CFS

FMMM1 said:
However, I think recently Robert Phair, and Chris Armstrong, have been trying to establish whether increased hydroxyproline is the result of collagen breakdown or the body increasing collagen synthesis.
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I would think the whole turn-over machinery of collagen is elevated, and even both could be the case.

A further finding which could be a hint here is: Association of [CFS] with premature telomere attrition, Rajeevan et al 2018, though this is only on cells from blood (all cells though). A further restriction is that mostly women accounted for the difference to HC´s, so one would like to explain why telomeres from cells in women and men which have been broken down are found rather only in the blood from women - probabaly not a very convincing path to go down.
 
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