Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome - Mar 2019 - Yasui et al

With this particular study I don't feel it`s unfair because it`s so blatantly apparent that the method used is bizarre. What is the reasoning behind thinking that rats will get ME by splashing in water? I mean rats live in the sewers just fine, but the wastewater isn't 1 celcius like in this study Id be feeling pain too if i had my legs in that temperature for 6 days

 

Exactly. This looks like a model for burnout, or even PTSD: prolonged stress + exhaustion = ???