Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in CFS, 2018, Barnden et al

Like tinnitus and narcolepsy....two dieseases with no cure.....ugh...

https://tonic.vice.com/en_us/article/59ypvn/were-taking-the-first-steps-toward-a-cure-for-narcolepsy

 

Thanks for your interpretations. Do you know of any research on what causes such loss in myelin in the brain/brainstem?

 

No, it is not an area I know about in detail.

 

https://twitter.com/user/status/1030834136666333185

 

We need

Michael VanElzakker

 

Michael's response is very interesting too:

https://twitter.com/user/status/1030930651455913985


He talks about how the part of the brain highlighted in this study 'samples' circulating cytokines, and links everything to astrocytes and microglia.

I definitely get the sense that we're onto something that might be elucidated soon.

 

https://twitter.com/user/status/1030932089632448518


https://twitter.com/user/status/1030971341892190208


https://twitter.com/user/status/1031001409360146432


https://twitter.com/user/status/1031002591180849152


https://twitter.com/user/status/1031004381754417152

 

https://twitter.com/user/status/1031005022476283904


And he specifically responds to the idea of non-cytolytic EVs here:

https://twitter.com/user/status/103093371849039462


He seems to link this to the Nakatomi findings.

 

I understood in the paper, indeed, the brainstem signal wasn't quite expected, so maybe they were hoping to find something else but found this. If I remember correctly they are suggesting another technique to follow this up. So, taken together, another study should go on as Michael vanElzekker suggests?

 

I think so. I'm trying not to get excited but it looks interesting.

 

Thanks for these Twitter posts. Quite interesting!

Edit: Does this mean there could be a leaking blood brain barrier?

 

I'm not seeing the last tweet you posted(?)

 

Thank you, @adambeyoncelowe . Sounds really interesting. But what are "EVs"?

 

Enteroviruses?
I can't see the twitter post either.

 

when clicked to twitter message is that page does not exist

 

It's been deleted from Twitter. He said they may be a cause for a minority, but that's it. I know he theorises that neurotropic viruses can infect the vagus nerve, and he thinks the brainstem changes are around/near that point.

 

seems to have just moved:
https://twitter.com/user/status/1030932218233860096

 

https://twitter.com/user/status/1030933718490394624

https://twitter.com/user/status/1031192782042488832