IDO2 gene mutations - SNPs

[jamari]

Not strictly IDO2, but this 2008 paper https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-2-95 identifies TPH2 as a gene of interest


TPH2 is responsible for breaking down tryptophan. I have a couple very uncommon snps there (one is 0% but I think that must be a mistake).

Interesting..

I did read that TPH2 was statistically significant in development of ME/CFS.
TPH1/TPH2 is responsible for || Trypophan + TPH1/TPH2 --> 5-HTP --> Serotonin ||

Dr Phair's paper did suggest that TPH1 is also substrate inhibited, like IDO1.

"This is because TPH1 is, itself, substrate inhibited at high concentrations of its substrate, tryptophan [51,52]."

51. Windahl, M.S.; Boesen, J.; Karlsen, P.E.; Christensen, H.E.M.; Christensen, H.E.M. Expression, Purification and Enzymatic Characterization of the Catalytic Domains of Human Tryptophan Hydroxylase Isoforms. Protein J. 2009, 28, 400–406. [CrossRef]
52. McKinney, J.; Knappskog, P.M.; Haavik, J. Different properties of the central and peripheral forms of human tryptophan hydroxylase. J. Neurochem. 2005, 92, 311–320. [CrossRef]