Inflammatory predictors of Post-COVID fatigue
A. Nuber-Champier, G. Breville, P. Voruz, I. Jacot de Alcântara, P.H. Lalive, G. Allali, L. Benzakour, K.-O. Lövblad, O. Braillard, M. Nehme, M. Coen, J. Serratrice, J.-L. Reny, J. Pugin, I. Guessous, B.N. Landis, A. Cionca, F. Assal, J.A. Péron
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Highlights
• TNFα levels are associated with fatigue awareness.
• Monocyte percentage predicts subjective fatigue.
• Different inflammatory markers are associated with different dimensions of fatigue.
Abstract
The biological mechanisms underlying objective and subjective fatigue in post-COVID syndrome remain unclear. This study investigates whether immune responses during the acute phase of SARS-CoV-2 infection predict fatigue dimensions 6–9 months post-infection.
We analyzed serum immune markers from 54 hospitalized patients (mean age: 58.69 ± 10.90 yrs; female: 31 %) and assessed their association with chronic fatigue using general linear mixed models.
Elevated levels of IL-1RA, IFNγ, TNFα, and monocyte percentage during acute infection predicted increased physical and total fatigue. Additionally, higher TNFα levels (r = −0.40, p = .019) correlated with reduced awareness of cognitive fatigue.
These findings highlight the role of acute inflammation in the persistence of post-COVID fatigue.
Web | PDF | Brain, Behavior, & Immunity - Health | Open Access
A. Nuber-Champier, G. Breville, P. Voruz, I. Jacot de Alcântara, P.H. Lalive, G. Allali, L. Benzakour, K.-O. Lövblad, O. Braillard, M. Nehme, M. Coen, J. Serratrice, J.-L. Reny, J. Pugin, I. Guessous, B.N. Landis, A. Cionca, F. Assal, J.A. Péron
[Line breaks added]
Highlights
• TNFα levels are associated with fatigue awareness.
• Monocyte percentage predicts subjective fatigue.
• Different inflammatory markers are associated with different dimensions of fatigue.
Abstract
The biological mechanisms underlying objective and subjective fatigue in post-COVID syndrome remain unclear. This study investigates whether immune responses during the acute phase of SARS-CoV-2 infection predict fatigue dimensions 6–9 months post-infection.
We analyzed serum immune markers from 54 hospitalized patients (mean age: 58.69 ± 10.90 yrs; female: 31 %) and assessed their association with chronic fatigue using general linear mixed models.
Elevated levels of IL-1RA, IFNγ, TNFα, and monocyte percentage during acute infection predicted increased physical and total fatigue. Additionally, higher TNFα levels (r = −0.40, p = .019) correlated with reduced awareness of cognitive fatigue.
These findings highlight the role of acute inflammation in the persistence of post-COVID fatigue.
Web | PDF | Brain, Behavior, & Immunity - Health | Open Access