Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics, 2018, Lipkin et al

Re the symptoms of swollen glands and fevers, makes sense they’d be related to what kicked off the ME, as well as possibly the length of illness. I believe my case started with an enteroviral illness.

 

See, this is where we're all different. I had the initial viral/vertigo/mild sore ear/sore throat onset for 5-6yrs. Then the relapse 7yrs later from taking immune modulators which brought on autonomic dysfunction, this and PEM are the most debilitating symptoms for me.

For the last 15 years my ears/glands are inflamed and sore 80% of the time after 27 years of illness. And the vertigo keeps coming back even worse than before.

 

Has anyone tried ordering B5? "Use of vitamin B supplements was associated with higher levels of pantothenic acid and lower fatigue scores (data not shown)."

 

One of the main symptoms of my PEM is swollen and painful lymph nodes. This is often accompanied by drenching night sweats and fever dreams. My normal body temperature is low (in hospital every nurse thought the electronic thermometer was broken when the got my result).

I am EBV negative and had a Coxsackie B onset many years ago

 

I had a brief look at this paper earlier; it looks like a bit of a monster i.e. there a lot of information here.

I wonder if these findings fit in with Ian McGregor's theory (emerge conference last month) that ME is chronic sepsis. I.e. leaky gut produces chronic sepsis; altered metabolism (energy production) failure of muscles to take up oxygen ----. Here's an article which deals in clearer language (for lay people - I'm one) with this subject - sphingolipids, ceramides --- gut bugs --:
https://www.omf.ngo/2017/10/19/treating-autism-and-mecfs-could-one-drug-do-both/

 

Running trend in these kind of studies, seems to me, to be disturbances to lipid utilisation and maybe the TCA cycle?