To the Editor,
We were interested to read the article by Zhou et al on a retrospective observational study comparing demographic and socioeconomic characteristics, prepandemic comorbidities and new-onset disease between patients with internal tremor and vibration as symptoms of Long COVID and patients with Long COVID but without internal tremor or vibration.
1 It was found that 37% of patients with long-COVID reported internal tremor or vibration, that patients with internal tremor had lower quality of life (QoL) scores than patients without tremor, and had a higher rate of new-onset mast cell dysfunction.
1 The study concluded that patients with long-term COVID who manifest with internal tremor and vibration have different conditions and symptoms and poorer health than patients without these symptoms.
1 The study is excellent, but some points should be discussed.
...
To summarize, this interesting study has limitations that put the results and their interpretation into perspective. Addressing these limitations could strengthen the conclusions and corroborate the study's message. Patients with prolonged COVID manifesting with internal tremor and vibrations need a thorough and comprehensive diagnostic workup to avoid overlooking a CNS/PNS or psychiatric disorder as the cause of these symptoms.
Open access