I prefer good studies to anecdotal evidence, but here goes...
I've been using LDN for several months, ramping up to a 4.5 mg a day dose.
I haven't noticed any side effects, even while ramping up.
I'd say my general energy level has improved. I am more likely to just make a phone call, rather than procrastinating and having a sense of dread about its difficulty. At the same time cognitive tasks haven't improved. I still don't read books, try to learn a new language or do much computer programming (which I like a lot).
On the PEM side I'm still a bit uncertain. I do have more energy when I do physical activity, but my daily hour or two in both morning and afternoon of lying down in a completely quiet room hasn't changed.
For the last several years I've had what I call the "full body burn". It almost feels like the old peripheral neuropathy has slowly moved to my core, most noticeably when lying down. This has also decreased with LDN.
The note about skin problems is interesting. I was making notes for the next doctor visit and had two comments about skin problems being resolved. I've had a continuing rash in a moist area for several years. Daily applications of antifungal cream, occasional use of flucanazole (an antifungal), hexadrene soap... nothing kept it away. Since LDN the rash has completely disappeared. For the last ten years my forearms have had an itch. I describe it as a single errant pain sensor, like someone poking you with a pin every 15 seconds. Nothing would relieve the itch. I tried every cream, salve and topical medication available over the counter and nothing worked. Again, since starting LDN, the itch is gone.
I'm always very skeptical of any drug I try. Often they seem to work for a while, because when you're so low, almost anything feels like an improvement. The warning sign for me is when you start to increase the dosage. I feel this means that the treatment is only temporarily making you feel good at the expense of a slow drain on overall energy.
