ME/CFS Science Blog article - Immune findings in ME/CFS

This was a really good and necessary article. I really hope it sunk in with some of the people who are pushing inflammation and viral persistance etc.

I did think there were a few notable omissions unless I missed them:

The finding of higher cd38 and cd24 in MECFS B cells.

Jackie Cliff's T cell findings.

The T cell dependant IFNy long covid finding from 2024 that Rosetta Stone may be trying to replicate.
 
V.R.T. said:
I really hope it sunk in with some of the people who are pushing inflammation and viral persistance etc.
Click to expand...

"We just haven't checked in all possible tissues yet. We just need the right combination of antivirals. We're looking for magic antibodies that haven't been discovered yet. We have different sub groups so our approach works, but we haven't identified the right patients."

My impression is that most people in the field care more about their ideology than producing results. Just like doctors they can't admit when they were wrong or don't know something.
 
Dude said:
For Example:
In Graves’ disease (Morbus Basedow), antibodies activate the TSH receptor. Here, it is not the level alone that matters, but the functional effect at the receptor.
Click to expand...
Seems like a bad example because the population level differences in TRabs between healthy people and people with Graves disease are massive and unlike anything seen in ME/CFS. The differences are so big that they are used for diagnosis even if the don't tell you everything about a single person and even if there may be deviations from the norm in any given individual. As has been mentioned countless of times before if you discount marginal differences in GPCR-aab because the argument is that population level differences don't matter, then you have no evidence for their role to begin with expect for of course negative evidence from B-cell trials.
 
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