Chandelier
Senior Member (Voting Rights)
Metformin for fatigue and cognitive dysfunction associated with postCOVID-19 condition and other suspected mitochondrial dysfunction: a case series
Stahl, James E.
This and other similar syndromes seem to involve immunologic, metabolic and neurologic causes.
Evidence-based therapies remain limited.
In each case, symptoms recurred on metformin discontinuation and improved again after re-initiation.
Web | DOI | Research Square | Open Access
Stahl, James E.
Abstract
Background
PostCOVID-19 condition (long COVID) is commonly associated with persistent fatigue and cognitive dysfunction.This and other similar syndromes seem to involve immunologic, metabolic and neurologic causes.
Evidence-based therapies remain limited.
Case presentation:
We report three women with severe fatigue and cognitive dysfunction (two following COVID-19 and one temporally associated with aromatase inhibitor therapy) in whom metformin was associated with rapid, clinically meaningful improvement.In each case, symptoms recurred on metformin discontinuation and improved again after re-initiation.
Conclusions
These observations support further evaluation of metformin for fatigue and cognitive dysfunction in selected patients with post-viral syndromes or suspected mitochondrial impairment.Web | DOI | Research Square | Open Access