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No Benefit of 3 Commonly Used Medications in MS Fatigue

Discussion in 'Other health news and research' started by Jaybee00, Aug 9, 2020.

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  1. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    Jaybee00, Aug 9, 2020
    #1
    hellytheelephant, MEMarge, ScottTriGuy and 2 others like this.
  2. Trish

    Trish Moderator Staff Member

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    Trish, Aug 9, 2020
    #2
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  3. InitialConditions

    InitialConditions Senior Member (Voting Rights)

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    It needs to be stated again that medicine really doesn't understand fatigue, nor know how to treat it.
     
    InitialConditions, Aug 9, 2020
    #3
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  4. rvallee

    rvallee Senior Member (Voting Rights)

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    The drugs: amantadine, modafinil, methylphenidate. Not surprised about the last 2 not being effective, never heard of the first.

    Just like pain, the entire field of fatigue research needs a complete reset. You can't progress without a basic understanding of what it is, starting with a damn common and clear vocabulary. Literally start over from scratch with a fresh batch of people, there's nothing of value to be found in there yet.

    Case in point:
    Fatigue is not sleepiness. Just. Stop. You are very bad at this. :banghead:

    Wait, no, I meant :banghead::banghead::banghead::banghead::banghead::
    Actually what I meant is: :banghead::banghead::banghead::banghead::banghead::banghead::banghead::banghead::banghead:
    Have you literally never checked the scientific literature on this topic? Seriously?
     
    Last edited: Aug 9, 2020
    rvallee, Aug 9, 2020
    #4
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  5. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    Stimulants are pretty effective for things like narcolepsy, etc., so there are some treatments available for certain conditions.
     
    Jaybee00, Aug 9, 2020
    #5
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  6. chrisb

    chrisb Senior Member (Voting Rights)

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    Amantadine was ried in ME. I don't know whether there was ever a trial, but it was not beneficial.
     
    chrisb, Aug 9, 2020
    #6
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  7. rvallee

    rvallee Senior Member (Voting Rights)

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    rvallee, Aug 9, 2020
    #7
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  8. Mij

    Mij Senior Member (Voting Rights)

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    I think it was Dr. Paul Cheney who rx'd Amantadine (antiviral) usually used to treat Type-A influenza virus and is sometimes used in ME/CFS for its stimulating properties.
     
    Mij, Aug 9, 2020
    #8
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  9. Snowdrop

    Snowdrop Senior Member (Voting Rights)

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    Yes, I keep thinking of that quoted tweet of Dr Amy Small (I think IIRC)

    Having long-covid symptoms she acknowledged that as a dr she had no idea what people meant when talking about post viral fatigue. Fatigue seemed inadequate. I'm restating this but I believe this was the gist.

    Doctors inevitably think that people who come in with chronic symptoms of pain and / or fatigue are equivalent to what they have experienced in their lives if they ever had these symptoms in some acute illness or physical trauma.
     
    Last edited: Aug 10, 2020
    Snowdrop, Aug 9, 2020
    #9
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  10. Amw66

    Amw66 Senior Member (Voting Rights)

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    This
     
    Amw66, Aug 9, 2020
    #10
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  11. Mithriel

    Mithriel Senior Member (Voting Rights)

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    It was used to treat herpesvirus and cocaine addiction so it was embarrassing to collect from the chemist :)

    I was given it in 1985 but it did not help my fatigue. It may have influenced my results that I had a 9 month old baby who slept for 2 hours a day.
     
    Mithriel, Aug 10, 2020
    #11
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