OMF Funds ME/CFS Collaborative Research Center at Uppsala

John Mac

John Mac

Senior Member (Voting Rights)
Received this email from OMF

We are proud to announce that OMF has funded the establishment of a third ME/CFS Collaborative Research Center, at Uppsala University in Sweden.

The new Uppsala Center will be led by OMF Scientific Advisory Board member Jonas Bergquist, MD, PhD and will work synergistically with the ME/CFS Collaborative Research Center at Stanford led by Ronald W. Davis, PhD, and the ME/CFS Collaborative Research Center at Massachusetts General Hospital and Harvard Affiliated Hospitals, led by Ronald G. Tompkins, MD, ScD, and Wenzhong Xiao, PhD of Harvard University. All science funded by OMF continues to be under the overall direction of our Scientific Advisory Board, directed by Ron Davis.

This new Collaborative Center focuses on the targeted molecular diagnosis of ME/CFS with the goal of evidence-based strategies for interventions. In Uppsala, significant efforts are being brought to bear on the analysis of cerebrospinal fluid as a unique source of neurochemical biomarkers of ME/CFS. High-resolution mass spectrometry will be used for extremely sensitive detection of endogenous biomolecules. This unique technology, in combination with the development of clinically relevant screening and targeted methods for sampling, will deliver previously unattainable insights into the pathophysiology of ME/CFS.
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I've been meaning to ask - have there been any metabolic studies of cerebral spinal fluid yet? I remember hearing about one, I think but I can't remember.
 
dreampop said:
I've been meaning to ask - have there been any metabolic studies of cerebral spinal fluid yet? I remember hearing about one, I think but I can't remember.
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There was one study about proteomics in the cerebrospinal fluid. Professor Bergquist was a coauthor:
Schutzer SE, Angel TE, Liu T, et al. Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome. PLoS One. 2011;6(2):e17287.

The article is open access: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017287
 
The local newspaper Upsala Nya Tidning has an article about the ME/CFS Collaborative Research Center today.

Forskning kring ME får centrum i Uppsala
google translation: Research into ME gets a center in Uppsala

The Uppsala Center will be the third funded by the Open Medicine Foundation and the first to be located outside the US. The first two are linked to Stanford university and Harvard university.

- However, our center is much smaller than these, at least initially. The funds will initially be used to finance a doctoral student service, which is the first of its kind in Swedish ME research, says Jonas Bergquist.

The three centers will cooperate with each other, although based on a small number of different research profiles. The platform in Uppsala will primarily research around so-called biomarkers in the spinal fluid in patients with ME.
 
just randomly looking at stuff on 'exosomes' and came across this reference (2018)
New mechanism by which Alzheimer's disease spreads through the brain discovered

The Linköping researchers have shown in the new study that exosomes can also transport toxic aggregates of the protein amyloid beta, and in this way spread the disease to new neurons.
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In a collaboration with researchers at Uppsala University, he and his co-workers have investigated exosomes in brain tissue from deceased persons.
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https://www.sciencedaily.com/releases/2018/06/180613113753.htm
 
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