Overview of ME/CFS genes in DecodeME

[hotblack]

Human Protein Atlas page for SRSF11 brain expression and it shows low tissue specificity, so its everywhere. Also widely expressed outside the brain. Apparently involved in mRNA processing and splicing but it’s not clear amd the data is quite old.

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010

I’d certainly be interested in understanding more about why AG2 picked this up and what the wider analysis involved.

 

[ChronicallyOverIt]

So I have results from AG2 but I do not know if it is prudent to post them as they are the product of an AI generated colab code which utilises AG2 API .

One thing to comment, a gene called SRSF11 -which came up to the analysis- and its effect to GABAergic neurons which has not been discussed anywhere in the forum (to the best of my knowledge).

If anyone else's analysis -who has the necessary background- identifies this gene, I could share the rest of results.

Probably deserves its own thread with methods, git repo, and explanation! Sounds interesting

 

[tralfamadorian97]

My question had been how and who has the expertise to do this. AI tools are definitely helpful and maybe they’d be helpful enough for a few of us to do this? I also wondered if we could get a professional research team interested as it seems like a great project for someone. What do @mariovitali and @ME/CFS Science Blog think? Maybe @tralfamadorian97 and @forestglip too?

At least from a cursory glance at the paper and blog post, AlphaGenome 2 does sound like it has potential. Right now I am focused on the proteomics GWAS work. If my contribution would be helpful, I should be able to try out AG2 when I am done with proteomics.

 

[SugarSquared]

At least from a cursory glance at the paper and blog post, AlphaGenome 2 does sound like it has potential. Right now I am focused on the proteomics GWAS work. If my contribution would be helpful, I should be able to try out AG2 when I am done with proteomics.

Is there any way we can support your work? You and @ME/CFS Science Blog work so hard and I would like to show my appreciation if I can.