Overview of ME/CFS genes in DecodeME

[hotblack]

Human Protein Atlas page for SRSF11 brain expression and it shows low tissue specificity, so its everywhere. Also widely expressed outside the brain. Apparently involved in mRNA processing and splicing but it’s not clear amd the data is quite old.

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010

I’d certainly be interested in understanding more about why AG2 picked this up and what the wider analysis involved.

 

[ChronicallyOverIt]

So I have results from AG2 but I do not know if it is prudent to post them as they are the product of an AI generated colab code which utilises AG2 API .

One thing to comment, a gene called SRSF11 -which came up to the analysis- and its effect to GABAergic neurons which has not been discussed anywhere in the forum (to the best of my knowledge).

If anyone else's analysis -who has the necessary background- identifies this gene, I could share the rest of results.

Probably deserves its own thread with methods, git repo, and explanation! Sounds interesting