Overview of RNA datasets for tissue and cell type enrichment analysis

[ME/CFS Science Blog]

Did an analysis of the chromatin openness (sc-ATAC-seq) rather than RNA in the brain atlas by Li et al. 2023. The main results look like this:


For the full analysis see the thread here:
A comparative atlas of single-cell chromatin accessibility in the human brain, Li et al, 2023 | Science for ME

 

[ME/CFS Science Blog]

Did an analysis of new basal ganglia brain atlas from the BRAIN Initiative Cell Atlas Network (BICAN), discussed here:
Massive atlas of brain region linked to a host of diseases is the most detailed yet | Science for ME

The human data is from 10 donors with RNA reads from 1.03 million nuclei organised into 453 clusters, 60 groups, 36 subclasses, 12 classes, and 4 neighbourhoods.

Overall I think it supports previous analyses that the (eccentric) medium spiny neurons in the striatum are among the cell types that best matches the DecodeME data, but it doesn't seem to add much new.