Profile of circulating microRNAs in Myalgic Encephalomyelitis......(2020)Moreau et al

Merged thread

I don't know if this is anything new from earlier challenges:

  • MicroRNA (miRNA) are small bits of RNA which turn on or off the expression of genes. They accumulate over time and may during our lifetimes affect half of our genes.
  • The question regarding miRNA is whether an alteration in miRNA expression during an infection, say, caused a kind of biological reset.
  • This Montreal study used a kind of massager to induce PEM in people with ME/CFS too ill to participate in the exercise stressors typically used in studies.
  • The massager appeared to work. Not only did the people with ME/CFS report an increase in symptoms afterwards (while the healthy controls did not), the study was able to use the differences in miRNA found to effectively predict who had ME/CFS and who was healthy.
  • The finding suggested that the exertion stressor altered the miRNA in ME/CFS patients much more than it did the healthy controls (which intuitively makes sense), and that exertion in ME/CFS may particularly affect inflammation and the immune system. A possible intriguing link to inflammation of the blood vessels was found.
  • The study was also able to use it’s miRNA findings to differentiate four types of ME/CFS including a more severely ill, severely ill group with increased fatigue, PEM, poorer sleep and functioning.
Click to expand...

https://www.healthrising.org/blog/2...flammation-exertion-chronic-fatigue-syndrome/
 
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