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Rapid improvement in severe long COVID following perispinal etanercept, 2022, Tobinick et al

Discussion in 'Long Covid research' started by Braganca, Jul 6, 2022.

  1. Braganca

    Braganca Senior Member (Voting Rights)

    Messages:
    135
    https://www.tandfonline.com/doi/abs/10.1080/03007995.2022.2096351

    This study aimed to describe the neurological improvements in a patient with severe long COVID brain dysfunction following perispinal etanercept administration. Perispinal administration of etanercept, a novel method designed to enhance its brain delivery via carriage in the cerebrospinal venous system, has previously been shown to reduce chronic neurological dysfunction after stroke. Etanercept is a recombinant biologic that is capable of ameliorating two components of neuroinflammation: microglial activation and the excess bioactivity of tumor necrosis factor (TNF), a proinflammatory cytokine that is a key neuromodulator in the brain. Optimal synaptic and brain network function require physiological levels of TNF. Neuroinflammation, including brain microglial activation and excess central TNF, can be a consequence of stroke or peripheral infection, including infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19.
     
    SNT Gatchaman, mango, Hutan and 4 others like this.
  2. Creekside

    Creekside Senior Member (Voting Rights)

    Messages:
    347
    I expect there would be plenty of volunteers from the ME community who would be willing to give this a try. If it doesn't help significantly, at least it would eliminate some theories.
     
    Hutan, alktipping, Binkie4 and 4 others like this.
  3. LarsSG

    LarsSG Senior Member (Voting Rights)

    Messages:
    190
    Nancy Klimas is trialing Etanercept and Mifepristone in GWI, though presumably not with this special injection method.
     
    Hutan, alktipping, Braganca and 2 others like this.
  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    11,402
    Location:
    London, UK
    I think etanercept has been tried in ME before with no useful effect.

    Perispinal administration sounds highly risky to me and unjustified in the absence of any evidence of inflammation.
     
    FMMM1, Lilas, Aroa and 5 others like this.
  5. Andy

    Andy Committee Member

    Messages:
    17,084
    Location:
    Hampshire, UK
    Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Chronic Fatigue Syndrome

    "Recruitment Status : Terminated (After inclusion of four patients, two experienced moderate worsening of symptoms)"

    https://clinicaltrials.gov/ct2/show/NCT01730495
     
    FMMM1, Starlight, Lilas and 13 others like this.
  6. BurnA

    BurnA Senior Member (Voting Rights)

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    409
    Aroa, Braganca and Peter Trewhitt like this.

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