Research news from Bhupesh Prusty

Deficits/disturbances of innate immune system can produce a wide range of disorders, including neuropsychiatric disorders.

 

Too bad. Seems to me more researchers should spend time getting constructive criticism, instead of clinging to own hypothesises. This is not directed at Prusty by the way, just a general advice that would probably move the field forward

 

While I've been on twitter in the past and it has it's uses - I think BP would be much better served presenting any hypotheses, requests, findings, thoughts etc here. Just my opinion though.

 

I agree, but I guess we're biased!
Still possible he might change his mind in future I suppose.

 

I just don't see the need for a nonspecific hypothesis, but in any case you would think his research has been public and specific enough that his position is established in those areas. That and the me community is small and knowleadgable, we know what few researchers have contributed and try to champion them. Personally the grand statements are off-putting.

Moving on, he asks about Eosinophlic Catanonic Protein in ME/CFS and people responded with some very specific published work

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1398-9995.1996.tb04570.x

https://www.tandfonline.com/doi/abs/10.1300/J092v09n01_03

 

@Jonathan Edwards responded to a question I'd asked - haven't found Jonathan's post yet. Basically (from memory) he was highlighting that there is specialisation in T-cells e.g. MAIT cells are associated with mucosa. Jonathan was suggesting that a specialised class of T-cells, which were responsible for interpreting responses from other immune cells (command & control if you like), would produce something like that looks like ME. I.e. the system seems to be responding to a threat but it's actually responding to dysfunction in the command & control system.

 

Prusty removed the complement pathway and the mitochondria went back to normal in his experiment. Thats a pretty big deal in my book tbh. I hope that ppl like Ron or alain moreau can recreate this with their Cfs model very soon. Definitely a lead that should be followed fast now.

 

What’s the complement pathway?

 

If you have genes related to dementia risk (APOE)ect,are you more likely to develop M.E
And severe COVID as a few papers have suggested.
https://www.sciencemediacentre.org/...ovid-19-and-a-faulty-gene-linked-to-dementia/
I may have risk due to PITX2 but I think this paper is about atrial fibrillation
https://onlinelibrary.wiley.com/doi/abs/10.1111/pace.12537
Do they all have a distant effect on FOXO

 

Code:

https://twitter.com/BhupeshPrusty/status/1314565018491539456

https://twitter.com/user/status/1314565018491539456

Code:

https://twitter.com/BhupeshPrusty/status/1314565019888168968

https://twitter.com/user/status/1314565019888168968


Bit too much overly hopeful thinking in those tweets for my liking.

 

Indeed. It's hard for me to take him seriously, which is a shame because I'm sure he means well.

 

I don't see why someone couldn't put together a diagnostic test in a short amount of time, if they knew what the something in the blood is.

How good the diagnostic test will be is another question and he is aware of that.

 

https://www.intechopen.com/books/a-...-angioedema-the-role-of-the-complement-system

Looking through the paper above I discovered I may have a partial complement deficiency factor (I) at 4q25
(A minor immune deficiency that you tend to grow out of)
https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-7-42#:~:text= Characterization of new mutations and the first,the five families studied have complete... More

https://nn.neurology.org/content/7/...GCyvmswY-PdwDcXDLtnKt_lAxUveIfH-p6z0WoPV2t59k
aHUS atypical hemolytic uremic syndrome is mentioned in the paper above and is treated with Ravulizumab the new COVID trial drug

 

https://www.hindawi.com/journals/aurt/2012/868576/
High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders

 

Maybe subtle immune complement deficiencies are widespread
Are problems fighting bacteria in early life an indicator along with allergies(hay fever)
Is it those with subtle complement deficiencies that get worse COVID and does that include long COVID
I saw a trial using Eculizumab for severe COVID and wonder if it might be effective for long COVID (and ME)

 

https://twitter.com/user/status/1341102713648652289


https://twitter.com/user/status/1341103784370515969


https://twitter.com/user/status/1341105620087398402


https://twitter.com/user/status/1341105623937773570

 

skeptical of this. And this

 

Well, for the end of 2020 i will take the optimism and (metaphorically) run with it. It’s been a bad year and we need very good news soon...