Research news from Bhupesh Prusty

Deficits/disturbances of innate immune system can produce a wide range of disorders, including neuropsychiatric disorders.
 
I just don't see the need for a nonspecific hypothesis, but in any case you would think his research has been public and specific enough that his position is established in those areas. That and the me community is small and knowleadgable, we know what few researchers have contributed and try to champion them. Personally the grand statements are off-putting.

Moving on, he asks about Eosinophlic Catanonic Protein in ME/CFS and people responded with some very specific published work

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1398-9995.1996.tb04570.x

https://www.tandfonline.com/doi/abs/10.1300/J092v09n01_03
 
strategist said:
What kind of problems can dysfunction of the innate immune system produce?
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@Jonathan Edwards responded to a question I'd asked - haven't found Jonathan's post yet. Basically (from memory) he was highlighting that there is specialisation in T-cells e.g. MAIT cells are associated with mucosa. Jonathan was suggesting that a specialised class of T-cells, which were responsible for interpreting responses from other immune cells (command & control if you like), would produce something like that looks like ME. I.e. the system seems to be responding to a threat but it's actually responding to dysfunction in the command & control system.
 
Prusty removed the complement pathway and the mitochondria went back to normal in his experiment. Thats a pretty big deal in my book tbh. I hope that ppl like Ron or alain moreau can recreate this with their Cfs model very soon. Definitely a lead that should be followed fast now.
 
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1. I am going to start a test on a novel diagnostic platform for ME, CFS and ME/CFS and long Covid over the next 2 months time. If it works as expected, we can have a robust quantitative diagnostic test in as less as 50-100 eur per sample and within 24h time.
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Code: 
https://twitter.com/BhupeshPrusty/status/1314565018491539456



2. It will also be possible to make it partially automated. I sincerely hope that it works as it has been working in a few pilot experiments so far. I am keen to have it as a Christmas gift for me and for all of you. Wish me good luck.
Click to expand...
Code: 
https://twitter.com/BhupeshPrusty/status/1314565019888168968



Bit too much overly hopeful thinking in those tweets for my liking.
 
I don't see why someone couldn't put together a diagnostic test in a short amount of time, if they knew what the something in the blood is.

How good the diagnostic test will be is another question and he is aware of that.
 
https://www.intechopen.com/books/a-...-angioedema-the-role-of-the-complement-system

Looking through the paper above I discovered I may have a partial complement deficiency factor (I) at 4q25
(A minor immune deficiency that you tend to grow out of)
https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-7-42#:~:text= Characterization of new mutations and the first,the five families studied have complete... More

https://nn.neurology.org/content/7/...GCyvmswY-PdwDcXDLtnKt_lAxUveIfH-p6z0WoPV2t59k
aHUS atypical hemolytic uremic syndrome is mentioned in the paper above and is treated with Ravulizumab the new COVID trial drug
 
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Maybe subtle immune complement deficiencies are widespread
Are problems fighting bacteria in early life an indicator along with allergies(hay fever)
Is it those with subtle complement deficiencies that get worse COVID and does that include long COVID
I saw a trial using Eculizumab for severe COVID and wonder if it might be effective for long COVID (and ME)
 
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