Trial Report Return to activities of daily living in patients with long covid: a randomized clinical trial, 2026, Constantini et al

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Return to activities of daily living in patients with long covid: a randomized clinical trial

Constantini, Marina Isolde; Rodrigues, Josiane; Benitez, Herber Orlando; Carminatti, Micheli; Sirydakis, Maria Eduarda de Moraes; Freitas, Cíntia de la Rocha; Danielevicz, Angelica; Delevatti, Rodrigo Sudatti

Introduction
Long covid is a concern due to persistent functional impairments. Physical exercise may mit-igate these effects; however, it is still necessary to understand how these benefits are perceived in the return to activities of daily living (ADLs).

Objective
To evaluate the return to impaired ADLs in survivors with long covid after a multicomponent physical training program.

Methods
A randomized controlled clinical trial conducted over 24 weeks. The Intervention Group (IG) participated in a multicomponent training program, while the Control Group (CG) received physical activity recommendations. ADLs were assessed using the Patient-Specific Functional Scale (0 = worst performance; 10 = best performance) at baseline, 12, and 24 weeks. Means were analyzed using Generalized Estimating Equations (α = 0.05).

Results
A total of 29 adults (16 women; 52.1 ± 13.9 years), previously hospitalized due to covid-19, participated, presenting persistent symptoms such as fatigue, dyspnea, myalgia, and memory loss, and reporting 2.8 ± 1.3 limited ADLs. Both groups showed improvement in ADLs over time (IG: baseline 15.0 ± 1.8 points; 12 weeks 20.7 ± 2.2 points; 24 weeks 22.5 ± 2.4 points | CG: baseline 10.7 ± 1.6 points; 12 weeks 17.6 ± 2.8 points; 24 weeks 20.8 ± 3.0 points), with no statistically significant differences between groups.

Conclusion
Improvements in ADL performance were observed in both groups over time, suggesting benefits associated with both structured training and physical activity recommendations, as well as a possible influence of the natural course of recovery, reinforcing the relevance of physical activity guidance in the rehabilitation of this population and clinical context.

Web | DOI | PDF | Revista Brasileira de Atividade Física e Saúde | Full text in Portuguese | Open Access
 
possible influence of the natural course of recovery
reinforcing the relevance of physical activity guidance in the rehabilitation of this population
?? this seems to be saying something like "we have no way to know if the exercise had anything to do with the improvement reported by these patients. Thus, this study provides evidence that exercise is effective."
 
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