Ron Davis’s big immune study is looking at HLA genes (HLA, WTF?) Here’s the story. [Simon M blog]

[Anna H]

Thank you very much. I'm particularly interested in whether Jonas mentions HLA or KIR sequencing. However, I'd pretty much be interested in any clues on how OMF research is going.

Jarred Younger's video presentation (in English at the same Conference) is interesting, their experiments (microglia activation) worked out - they're preparing to publish.

Jonas Bergquist only speaks briefly and in simplified terms about this, his talk is mostly aimed at giving an overview of current research and information about the new research center at Uppsala :

"A lot of research is also focused on the immune system, this is a selection of studies from Stanford, by Mark Davis, who works at Stanford University. The receptor system on the surface of immune cells is altered in ME/CFS patients, and this reduces the function of these cells and could also lead to erroneous signaling pathways in response to, for example, an antigen. "

 

[FMMM1]

Jonas Bergquist only speaks briefly and in simplified terms about this, his talk is mostly aimed at giving an overview of current research and information about the new research center at Uppsala :

"A lot of research is also focused on the immune system, this is a selection of studies from Stanford, by Mark Davis, who works at Stanford University. The receptor system on the surface of immune cells is altered in ME/CFS patients, and this reduces the function of these cells and could also lead to erroneous signaling pathways in response to, for example, an antigen. "

Thank you very much for the translation.

Interesting --- "The receptor system on the surface of immune cells is altered in ME/CFS patients, and this reduces the function of these cells and could also lead to erroneous signaling pathways in response to, for example, an antigen."

I suppose we'll just have to wait for more detail.

 

[FMMM1]

Ron Davis’s big immune study is looking at HLA genes (HLA, WTF?)
Anyone know when the data's due out?

EDIT - grant award was in the media end of June 2018 - 5 year grant---- OK some time to collate data & publish --- hopefully we'll see this in the next few months ---?

 

[Kitty]

The budget end date was 2019. Might that suggest that most of the practical work ought to have been completed by then and presumably the rest of the period was analysis and reporting? TBH, I don't really understand how research funding works.

 

[Andy]

From https://reporter.nih.gov/project-details/9577948

Project Start Date 15-June-2018
Project End Date 31-May-2023
Budget Start Date 15-June-2018
Budget End Date 31-May-2019

So the projected end of the project was the end of this month, so yes, if that schedule is being kept to, then we might be able to expect the results some time after the end of this month. How long after will depend on how long it takes to write it all up, how long it takes to get a journal to accept it, get it peer reviewed, and then finally publish it.