SequenceME genetic study - from Oxford Nanopore Technologies, the University of Edinburgh and Action for ME

[Jonathan Edwards]

How confident we are that ME/CFS has a strictly infectious origin ?

We aren't. Moreover the crucial importance of genetics in diseases of infectious origin is known by every medical student. Reiter's syndrome is the paradigm - very strongly predisposed to by HLA-B27. Then there is mannose binding protein deficiency and staph problems, HLA-DQ and post-influenza narcolepsy, lysosomal gene defects and chronic granulomatous disease and no doubt rheumatic fever and post-streptococal glomerulonephritis have genetic predispositions...

 

[V.R.T.]

HLA-DQ and post-influenza narcolepsy,

This would perhaps be an interesting connection to some of the things we've discussed recently but I assume the HLA DQ link didn't stand up in the separate analysis from what Chris apparently said at the Berlin conference.